{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:15:50Z","timestamp":1764260150307,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,30]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Fungal infections involving the pituitary gland are rare and can be life threatening. A 75-year-old man with hypertension and diabetes mellitus presented with headache and hyponatraemia. Imaging study showed right upper lung mass, and mass resection showed aspergilloma without tissue invasion on histology. The patient developed visual impairment a few weeks later, and MRI of the brain revealed bilateral sphenoid sinusitis and pituitary invasion. The trans-sphenoidal biopsy confirmed invasive <jats:italic>Aspergillus<\/jats:italic> infection. His sphenoidal sinuses were endoscopically debrided, and he was treated with oral voriconazole. Pituitary aspergillosis should be considered in the differential diagnosis in patients with lung aspergilloma with headache and sinusitis. Prompt biopsy and antifungal treatment are important due to the high mortality rate of the infection.<\/jats:p>","DOI":"10.1136\/bcr-2020-238721","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T12:36:05Z","timestamp":1611750965000},"page":"e238721","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Lung aspergilloma with pituitary invasive aspergillosis presenting as headache and hyponatraemia"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-7244","authenticated-orcid":false,"given":"Eunho","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-4392","authenticated-orcid":false,"given":"Sun Bean","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Kyung","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"2025082707464528000_14.1.e238721.1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"2025082707464528000_14.1.e238721.2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/alr.22172","article-title":"A multi-institutional review of outcomes in biopsy-proven acute invasive fungal sinusitis","volume":"8","author":"Wandell","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"2025082707464528000_14.1.e238721.3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.15406\/joentr.2018.10.00324","article-title":"Pituitary aspergillosis presenting as macroadenoma: case report and review of literature","volume":"10","author":"Kinberg","year":"2018","journal-title":"JOENTR"},{"key":"2025082707464528000_14.1.e238721.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-006-0811-8"},{"key":"2025082707464528000_14.1.e238721.5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jocn.2016.01.010","article-title":"Pituitary Aspergillus infection","volume":"29","author":"Moore","year":"2016","journal-title":"J Clin Neurosci"},{"key":"2025082707464528000_14.1.e238721.6","doi-asserted-by":"crossref","first-page":"E196","DOI":"10.1111\/tid.12129","article-title":"Pituitary aspergillosis in a kidney transplant recipient and review of the literature","volume":"15","author":"Vijayvargiya","year":"2013","journal-title":"Transpl Infect Dis"},{"key":"2025082707464528000_14.1.e238721.7","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.2214\/ajr.175.6.1751570","article-title":"Pituitary aspergillosis mimicking pituitary tumor","volume":"175","author":"Lee","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"2025082707464528000_14.1.e238721.8","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.170"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-238721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:46:52Z","timestamp":1756306012000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-238721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,27]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-238721"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-238721","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}