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Work-up was negative for hereditary or acquired angio-oedema, and imaging was negative for structural causes. Of note, the patient had an episode of severe orolingual swelling 3 months prior to this presentation after suffering left thalamic haemorrhage which self-resolved after approximately 2\u2009months. In both episodes lingual swelling predated receipt of tissue plasminogen activator and she had discontinued ACE inhibitor therapy since her first episode of tongue swelling. Despite medical and supportive management, tongue swelling progressed during admission and the decision was made to allow the patient\u2019s tongue swelling to self-resolve.<\/jats:p>","DOI":"10.1136\/bcr-2020-238775","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T18:44:07Z","timestamp":1610477047000},"page":"e238775","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent macroglossia requiring tracheostomy after haemorrhagic basal ganglia stroke"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-8511","authenticated-orcid":false,"given":"Muyinat Y","family":"Osoba","sequence":"first","affiliation":[{"name":"Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-646X","authenticated-orcid":false,"given":"Alexander L","family":"Schneider","sequence":"additional","affiliation":[{"name":"Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borislav","family":"Alexiev","sequence":"additional","affiliation":[{"name":"Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro J","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"},{"name":"Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois, USA"},{"name":"Hugh Knowles Center for Hearing Research, Northwestern University, Evanston, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"2025082708151077000_14.1.e238775.1","doi-asserted-by":"crossref","unstructured":"Borzova E , Angioedema GCEH . 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