{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:05:38Z","timestamp":1776283538320,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:00:00Z","timestamp":1608422400000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,25]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Type 1 multiple endocrine neoplasia (MEN-1) syndrome is an autosomal dominant disease, associated with germline mutations in the MEN-1 tumour suppressor gene (encoding the menin protein). Recent studies, through a better characterisation of the functions of the menin protein, have started to demonstrate how changes in this protein may be related to breast cancer. We present the case of a patient whose diagnosis of MEN-1 syndrome was made during treatment for a breast tumour\u2014this diagnosis was obtained after finding multiple neoplastic lesions that fitted the MEN-1 syndrome spectrum, during the initial staging and subsequent follow-up of a breast tumour. In line with the growing evidence that links MEN-1 syndrome to breast cancer tumorigenesis, this case report highlights the following question: should we start screening this subset of patients earlier for breast cancer?<\/jats:p>","DOI":"10.1136\/bcr-2020-238784","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:18:21Z","timestamp":1608661101000},"page":"e238784","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Incidental finding of MEN-1 syndrome during staging and follow-up of breast carcinoma"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-4787","authenticated-orcid":false,"given":"Bernardo Conde","family":"Maria","sequence":"first","affiliation":[{"name":"Surgery, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Catarina","family":"Quadros","sequence":"additional","affiliation":[{"name":"Pathology, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia","family":"Alves","sequence":"additional","affiliation":[{"name":"Surgery, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Surgery, Centro Hospitalar Lisboa Norte EPE, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"2025082709233800000_13.12.e238784.1","first-page":"105","article-title":"Multiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis","volume":"79","author":"Busygina","year":"2006","journal-title":"Yale J Biol Med"},{"key":"2025082709233800000_13.12.e238784.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1230"},{"key":"2025082709233800000_13.12.e238784.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00081-4"},{"key":"2025082709233800000_13.12.e238784.4","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5639-5649.2004"},{"key":"2025082709233800000_13.12.e238784.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408836102"},{"key":"2025082709233800000_13.12.e238784.6","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0061"},{"key":"2025082709233800000_13.12.e238784.7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3892\/ol.2014.2144","article-title":"Multiple endocrine neoplasia type 1 associated with breast cancer: a case report and review of the literature","volume":"8","author":"Jeong","year":"2014","journal-title":"Oncol Lett"},{"key":"2025082709233800000_13.12.e238784.8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/path.4146","article-title":"High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands","volume":"229","author":"Seigne","year":"2013","journal-title":"J Pathol"},{"key":"2025082709233800000_13.12.e238784.9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10549-009-0581-0","article-title":"Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistance","volume":"122","author":"Imachi","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"2025082709233800000_13.12.e238784.10","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4461"},{"key":"2025082709233800000_13.12.e238784.11","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0066"},{"key":"2025082709233800000_13.12.e238784.12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199709)183:1<30::AID-PATH1085>3.0.CO;2-K"},{"key":"2025082709233800000_13.12.e238784.13","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1210\/jc.2016-3690","article-title":"MEN1-Dependent breast cancer: indication for early screening? 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