{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:53Z","timestamp":1756339493829,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,3]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Juvenile respiratory laryngeal papillomatosis is a subset of a larger clinical entity of recurrent respiratory papillomatosis. It is characterised by the development of recurrent papillomata in the vocal folds. Human papillomavirus types 6 and 11 has been implicated to be the most common strain of virus associated with the formation of laryngeal papilloma. Clinical diagnosis is based on typical appearance of warty lesion on endoscopy. Surgery is the primary line of management along with adjuvant therapy like antiviral drugs and immunomodulators. Thuja occidentalis is a tree native to North America whose leaves and leaf oil have antiviral, antibacterial and antifungal properties. It has been widely used for the treatment of condylomatous skin lesions and warts. Here we discuss the outcome of thuja as an adjuvant therapy in the treatment of laryngeal papillomatosis in an 8-year-old child.<\/jats:p>","DOI":"10.1136\/bcr-2020-238846","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:18:21Z","timestamp":1608661101000},"page":"e238846","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Role of thuja in the management of laryngeal papilloma"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-3945","authenticated-orcid":false,"given":"Shivagamasundari","family":"Murali","sequence":"first","affiliation":[{"name":"ENT, Head and Neck Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8238-0419","authenticated-orcid":false,"given":"Prasanna Kumar","family":"Saravanam","sequence":"additional","affiliation":[{"name":"ENT, Head and Neck Surgery, Sri Ramachandra University Medical College, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-2627","authenticated-orcid":false,"given":"Nethra","family":"Dinakaran","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"2025082708143260000_13.12.e238846.1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.anorl.2018.01.002","article-title":"Laryngeal papillomatosis in Senegal: a ten-year experience","volume":"135","author":"Ma\u00efga","year":"2018","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"2025082708143260000_13.12.e238846.2","doi-asserted-by":"crossref","unstructured":"Gleeson M , Clarke R . Scott-Brown\u2019s Otorhinolaryngology: Head and Neck Surgery. 3. 7edn. CRC Press, 2008.","DOI":"10.1201\/b15118"},{"key":"2025082708143260000_13.12.e238846.3","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400608"},{"key":"2025082708143260000_13.12.e238846.4","first-page":"580","article-title":"Northern white-cedar","volume":"1","author":"Johnston","year":"1990","journal-title":"Silvics of North America"},{"key":"2025082708143260000_13.12.e238846.5","unstructured":"Kliegman RM , Behrman RE , Jenson HB , et al . Nelson textbook of pediatrics E- book. 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Hagers Handbuch Der Pharmazeutischen praxis: Drogen PZ Thuja. 5th edn. Berlin: Springer Verlag, 1994: 95566.","DOI":"10.1007\/978-3-642-57881-6"},{"key":"2025082708143260000_13.12.e238846.12","unstructured":"Boericke W . Boericke\u2019s New Manual of Homeopathic Materia Medica with Repertory: third revised and augmented edition based on ninth edition. 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