{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:33:39Z","timestamp":1779219219484,"version":"3.51.4"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,4]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Terbinafine is a commonly used antifungal medication. Its side effects, while widely known, are rarely described and can be missed by the medical community. We present a 55-year-old woman who visited her primary care physician with onychomycosis. She started treatment with terbinafine, and 1\u2009week later developed a rash in the left flank that extended to the chest, back, and upper part of lower extremities. Laboratory results showed elevated liver enzymes. A treatment with steroids did not improve the rash and she was admitted to our institution. She was started with intravenous dexamethasone, topical hydrocortisone and triamcinolone. Seven days later the liver enzymes normalised, and the rash resolved on the chest and back. Our patient had concurrent acute generalised exanthematous pustulosis and hepatitis that together has been very rarely associated with terbinafine.<\/jats:p>","DOI":"10.1136\/bcr-2020-238930","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T12:26:01Z","timestamp":1610972761000},"page":"e238930","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Concurrent terbinafine-induced acute generalised exanthematous pustulosis and hepatitis"],"prefix":"10.1136","volume":"14","author":[{"given":"Lorenzo R","family":"Carnio","sequence":"first","affiliation":[{"name":"Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E","family":"Johnson Shaw","sequence":"additional","affiliation":[{"name":"Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Schnur","sequence":"additional","affiliation":[{"name":"Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Casadesus","sequence":"additional","affiliation":[{"name":"Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2025082711223066000_14.1.e238930.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.017"},{"key":"2025082711223066000_14.1.e238930.2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081214","article-title":"Acute generalized exanthematous pustulosis: pathogenesis, genetic background, clinical variants and therapy","volume":"17","author":"Feldmeyer","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2025082711223066000_14.1.e238930.3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1310\/hpj5106-437","article-title":"Acute generalized exanthematous pustulosis due to labetalol; 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