{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:43:44Z","timestamp":1761129824968,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,27]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Hearing loss is an unusual presenting feature of <jats:italic>Cryptococcus gattii<\/jats:italic> meningoencephalitis. Two cases of HIV-negative patients who presented with hearing loss are discussed and a literature review of published cases was conducted. Possible mechanisms for hearing loss with <jats:italic>C. gattii<\/jats:italic> infection are explored. This case series aims to raise awareness among clinicians that hearing loss can be a concerning feature in patients with persistent headache necessitating further investigation.<\/jats:p>","DOI":"10.1136\/bcr-2020-239040","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T13:01:38Z","timestamp":1618578098000},"page":"e239040","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Hearing impairment as an unusual presenting sign of <i>Cryptococcus gattii<\/i> meningoencephalitis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8400-2526","authenticated-orcid":false,"given":"Sophie","family":"Gong","sequence":"first","affiliation":[{"name":"Internal Medicine, Queensland Health, Brisbane, Queensland, Australia"},{"name":"Infectious Diseases, Townsville Hospital and Health Service, Townsville, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirathaban","family":"Sivabalan","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Townsville Hospital and Health Service, Townsville, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damon P","family":"Eisen","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Townsville Hospital and Health Service, Townsville, Queensland, Australia"},{"name":"Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"2025082804083854000_14.4.e239040.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.07.010"},{"key":"2025082804083854000_14.4.e239040.2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.1.28"},{"key":"2025082804083854000_14.4.e239040.3","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.611"},{"key":"2025082804083854000_14.4.e239040.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.04.022"},{"key":"2025082804083854000_14.4.e239040.5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis529"},{"key":"2025082804083854000_14.4.e239040.6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028625","article-title":"Fatal disseminated Cryptococcus gattii infection in New Mexico","volume":"6","author":"Walraven","year":"2011","journal-title":"PLoS One"},{"key":"2025082804083854000_14.4.e239040.7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5847\/wjem.j.issn.1920-8642.2013.02.012","article-title":"Meningitis secondary to Cryptococcus gattii, an emerging pathogen affecting immunocompetent hosts","volume":"4","author":"Cookman","year":"2013","journal-title":"World J Emerg Med"},{"key":"2025082804083854000_14.4.e239040.8","doi-asserted-by":"crossref","DOI":"10.1136\/thoraxjnl-2018-212653","article-title":"Cryptic clues for an infection puzzle: from inside out","volume":"74","author":"Lee","year":"2019","journal-title":"Thorax"},{"key":"2025082804083854000_14.4.e239040.9","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2334-14-S2-P94","article-title":"Emerging virus coinfections of the CNS: HTLV I\/II as a common denominator","volume":"14","author":"Panos","year":"2014","journal-title":"BMC Infect Dis"},{"key":"2025082804083854000_14.4.e239040.10","first-page":"343","article-title":"Cryptococcal meningitis (C. neoformans var. gattii) leading to blindness in previously healthy Melanesian adults in Papua New Guinea","volume":"87","author":"Lalloo","year":"1994","journal-title":"Q J Med"},{"key":"2025082804083854000_14.4.e239040.11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.idh.2019.08.003","article-title":"CRyptOcoccosis in Newcastle and the hUnTer (CRONUT) - An epidemiological study","volume":"25","author":"Hughes","year":"2020","journal-title":"Infect Dis Health"},{"key":"2025082804083854000_14.4.e239040.12","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812442488"},{"key":"2025082804083854000_14.4.e239040.13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10792-012-9549-x","article-title":"Disseminated Cryptococcus with ocular cryptococcoma in a human immunodeficiency virus-negative patient","volume":"32","author":"Kresch","year":"2012","journal-title":"Int Ophthalmol"},{"key":"2025082804083854000_14.4.e239040.14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/01.mao.0000247816.23948.52","article-title":"Acute hearing loss due to cryptococcal meningitis in a patient with acquired immunodeficiency syndrome","volume":"28","author":"Linthicum","year":"2007","journal-title":"Otol Neurotol"},{"key":"2025082804083854000_14.4.e239040.15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000049266","article-title":"Cryptococcal meningitis: implications for the otologist","volume":"64","author":"Low","year":"2002","journal-title":"ORL"},{"key":"2025082804083854000_14.4.e239040.16","first-page":"435","article-title":"Cryptococcal meningitis: presentation as sudden deafness","volume":"6","author":"Maslan","year":"1985","journal-title":"Am J Otol"},{"key":"2025082804083854000_14.4.e239040.17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790030026006"},{"key":"2025082804083854000_14.4.e239040.18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.amjoto.2008.08.009","article-title":"Cryptococcal meningitis with isolated otologic symptoms","volume":"31","author":"Moberly","year":"2010","journal-title":"Am J Otolaryngol"},{"key":"2025082804083854000_14.4.e239040.19","unstructured":"Park M-G , Son J-Y , J-W J . A case of cryptococcal meningitis presenting as bilateral sensorineural hearing loss, 2006."},{"key":"2025082804083854000_14.4.e239040.20","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1017\/S002221511600801X","article-title":"Reversible hearing loss following cryptococcal meningitis: case study","volume":"130","author":"Neo","year":"2016","journal-title":"J Laryngol Otol"},{"key":"2025082804083854000_14.4.e239040.21","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1212\/01.wnl.0000168904.41046.2b","article-title":"The prognosis of hearing impairment complicating HIV-negative cryptococcal meningitis","volume":"65","author":"Wang","year":"2005","journal-title":"Neurology"},{"key":"2025082804083854000_14.4.e239040.22","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00126-13"},{"key":"2025082804083854000_14.4.e239040.23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/000348947908800507","article-title":"Temporal bone histopathology in deafness due to cryptococcal meningitis","volume":"88","author":"Harada","year":"1979","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"2025082804083854000_14.4.e239040.24","doi-asserted-by":"publisher","DOI":"10.3171\/2009.4.PEDS09103"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:08:48Z","timestamp":1756379328000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,16]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2020-239040"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239040","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}