{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:16:27Z","timestamp":1759335387212,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,30]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Two patients suffering from chronic recurrent tonsillitis were reported. The first patient was confirmed infected with COVID-19, 3 weeks prior to tonsillectomy. The detritus and tonsil specimen were further analysed through real-time PCR (RT-PCR) and revealed amplification of the fragment N and ORF1ab genes of SARS-CoV-2. The second patient had a negative IgM and positive IgG antibody for COVID-19; however, the nasopharyngeal swab indicated negative for SARS-CoV-2. Tonsillectomy was performed 2 weeks after the swab; the tonsil specimen was analysed through RT-PCR and revealed amplification of the N2 and RdRp gene of SARS-CoV-2. According to both results, the presence of the SARS-CoV-2 gene remains to be detected in tonsil and\/or detritus after 2\u20133\u2009weeks after recovery. Hence, it is suggested that it is necessary to use adequate protection when performing tonsillectomy on early recovered patients with COVID-19. Furthermore, tonsillectomy would be more advisable to be performed after the fourth week after recovery from COVID-19.<\/jats:p>","DOI":"10.1136\/bcr-2020-239108","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T10:13:31Z","timestamp":1612692811000},"page":"e239108","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["COVID-19 infection in the palatine tonsil tissue and detritus: the detection of the virus compartment with RT-PCR"],"prefix":"10.1136","volume":"14","author":[{"given":"Hamsu","family":"Kadriyan","sequence":"first","affiliation":[{"name":"Otolaryngology Head and Neck Surgery, Faculty of Medicine, Mataram University, Mataram, Nusa Tenggara Barat, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayu Tirta","family":"Dirja","sequence":"additional","affiliation":[{"name":"Microbiology, Mataram University Faculty of Medicine, Mataram, Nusa Tenggara Barat, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewi","family":"Suryani","sequence":"additional","affiliation":[{"name":"Microbiology, Mataram University Faculty of Medicine, Mataram, Nusa Tenggara Barat, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didit","family":"Yudhanto","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery, Faculty of Medicine, Mataram University, Mataram, Nusa Tenggara Barat, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"2025082703330133000_14.2.e239108.1","first-page":"23","article-title":"Upper respiratory tract sampling in COVID-19","volume":"42","author":"Mawaddah","year":"2020","journal-title":"Malays J Pathol"},{"key":"2025082703330133000_14.2.e239108.2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40463-020-00429-2","article-title":"Guidance for otolaryngology health care workers performing aerosol generating medical procedures during the COVID-19 pandemic","volume":"49","author":"Lammers","year":"2020","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"2025082703330133000_14.2.e239108.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40463-020-00425-6","article-title":"Clinical evidence based review and recommendations of aerosol generating medical procedures in otolaryngology \u2013 head and neck surgery during the COVID-19 pandemic","volume":"49","author":"Thamboo","year":"2020","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"2025082703330133000_14.2.e239108.4","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/hed.26184","article-title":"Framework for prioritizing head and neck surgery during the COVID-19 pandemic","volume":"42","author":"Topf","year":"2020","journal-title":"Head Neck"},{"key":"2025082703330133000_14.2.e239108.5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12070-017-1190-6","article-title":"Tonsillectomy-Comparative study of various techniques and changing trend","volume":"69","author":"Verma","year":"2017","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"doi-asserted-by":"publisher","key":"2025082703330133000_14.2.e239108.6","DOI":"10.1016\/j.ijid.2020.03.065"},{"unstructured":"Kementrian Kesehatan Republik Indonesia . Keputusan Menteri Kesehatan Republik Indonesia Tentang Panduan Pencegahan DAN Pengendalian COVID-19. 2020, 2019. Available: https:\/\/covid19.go.id\/storage\/app\/media\/Regulasi\/KMK No. HK.01.07-MENKES-413-2020 ttg Pedoman Pencegahan dan Pengendalian COVID-19.pdf [Accessed 3 Aug 2020].","key":"2025082703330133000_14.2.e239108.7"},{"key":"2025082703330133000_14.2.e239108.8","first-page":"566","article-title":"AAO-HNS guidelines for tonsillectomy in children and adolescents","volume":"84","author":"Randel","year":"2011","journal-title":"Am Fam Physician"},{"unstructured":"Sara T , Pasquale C , Michele G . ENT management of children with adenotonsillar disease during COVID-19 pandemic. ready to start again? Int J Pediatr Otorhinolaryngol 2020:1\u20134.","key":"2025082703330133000_14.2.e239108.9"},{"doi-asserted-by":"publisher","key":"2025082703330133000_14.2.e239108.10","DOI":"10.1002\/jmv.25825"},{"doi-asserted-by":"publisher","key":"2025082703330133000_14.2.e239108.11","DOI":"10.1053\/j.gastro.2020.02.055"},{"key":"2025082703330133000_14.2.e239108.12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/acschemneuro.0c00122","article-title":"Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms","volume":"11","author":"Baig","year":"2020","journal-title":"ACS Chem Neurosci"},{"doi-asserted-by":"publisher","key":"2025082703330133000_14.2.e239108.13","DOI":"10.1016\/j.cell.2020.04.035"},{"doi-asserted-by":"crossref","unstructured":"van Kampen JJ , van de Vijver DA , Fraaij PLA . Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants. medRxiv 2020:1\u201328.","key":"2025082703330133000_14.2.e239108.14","DOI":"10.1101\/2020.06.08.20125310"},{"unstructured":"Vi G , Morris CP , Wohl S . Repeat COVID-19 molecular testing: correlation of SARS-CoV-2 culture with molecular assays and cycle Thresolds. Clin Infect Disesase 2020.","key":"2025082703330133000_14.2.e239108.15"},{"key":"2025082703330133000_14.2.e239108.16","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/0194599820914275","article-title":"Effect of electrocautery settings on particulate concentrations in surgical plume during tonsillectomy","volume":"162","author":"Carr","year":"2020","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:33:10Z","timestamp":1756290790000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,5]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-239108"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239108","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}