{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:57:07Z","timestamp":1774353427110,"version":"3.50.1"},"reference-count":23,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,10,1]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>We report the first case of Guillain-Barr\u00e9 syndrome (GBS) associated with SARS-CoV-2 infection in Japan. A 54-year-old woman developed neurological symptoms after SARS-CoV-2 infection. We tested for various antiganglioside antibodies, that had not been investigated in previous cases. The patient was diagnosed with GBS based on neurological and electrophysiological findings; no antiganglioside antibodies were detected. In previous reports, most patients with SARS-CoV-2-infection-related GBS had lower limb predominant symptoms, and antiganglioside antibody tests were negative. Our findings support the notion that non-immune abnormalities such as hyperinflammation following cytokine storms and microvascular disorders due to vascular endothelial damage may lead to neurological symptoms in patients with SARS-CoV-2 infection. Our case further highlights the need for careful diagnosis in suspected cases of GBS associated with SARS-CoV-2 infection.<\/jats:p>","DOI":"10.1136\/bcr-2020-239218","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T17:01:40Z","timestamp":1603990900000},"page":"e239218","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Guillain-Barr\u00e9 syndrome after COVID-19 in Japan"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-3176","authenticated-orcid":false,"given":"Takehisa","family":"Hirayama","sequence":"first","affiliation":[{"name":"Department of Neurology, Toho University Omori Medical Center, Ota-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hongo","sequence":"additional","affiliation":[{"name":"Division of Neurology, Anti-aging, and Vascular Medicine, Department of Internal Medicine, National 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