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Bradykinin-mediated angioedema, such as hereditary or drug-induced angioedema, was excluded by a thorough history investigation and laboratory testing for C1-esterase and C4.<\/jats:p>\n               <jats:p>In rare cases, exogen pathogens cause angioedema. After profound testing for respiratory pathogens, <jats:italic>Bordetella pertussis<\/jats:italic> toxins IgA and IgG were found to be positive, indicating recent <jats:italic>B. pertussis<\/jats:italic> infection. Pertussis toxin may be responsible for increased vascular permeability causing angioedema. With adequate antibiotic treatment, the symptoms resolved quickly.<\/jats:p>\n               <jats:p>This case is an example of an atypical presentation of <jats:italic>B. pertussis<\/jats:italic> infection in an unvaccinated adult. The recent resurgence of pertussis makes early diagnosis and disease prevention by vaccination crucial.<\/jats:p>","DOI":"10.1136\/bcr-2020-239243","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:57:37Z","timestamp":1614682657000},"page":"e239243","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Angioedema as a predominant symptom of <i>Bordetella pertussis<\/i> infection"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3591-9490","authenticated-orcid":false,"given":"Christina","family":"Bal","sequence":"first","affiliation":[{"name":"Division of Pulmonology, Department of Medicine II, Vienna General Hospital of the Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-1421","authenticated-orcid":false,"given":"Ruth","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine II, Vienna General Hospital of the Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Gompelmann","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine II, Vienna General Hospital of the Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Idzko","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine II, Vienna General Hospital of the Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"2025082712241256000_14.3.e239243.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.02.032"},{"key":"2025082712241256000_14.3.e239243.2","article-title":"Pertussis: new preventive strategies for an old disease","volume":"29","author":"Di Mattia","year":"2019","journal-title":"Paediatr Respir Rev"},{"key":"2025082712241256000_14.3.e239243.3","unstructured":"European Centre for Disease Prevention and Control . 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