{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:04:32Z","timestamp":1782252272112,"version":"3.54.5"},"reference-count":8,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,21]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Rosai\u2013Dorfman disease is a rare benign histiocytic proliferative disease of unknown cause that, in exceptional cases, presents with lesions confined to the skin. Clinically variable types of lesions such as papules, nodules and plaques have been reported. We present a case of a 27-year-old woman with a 1-year history of erythematous papular and nodular lesions on the malar and right axillary regions, previously misdiagnosed as acne. She reported no fever, malaise or weight loss, while physical examination and laboratory workup were normal. Bacteriological and mycobacteriological cultures were negative. Histopathological findings showed dense infiltration of inflammatory cells involving the entire dermis, consisting of large macrophages with emperipolesis, S100 and CD68 positive, neutrophils, eosinophils, lymphocytes and plasma cells. The patient was treated with oral prednisolone without improvement. Dapsone was subsequently initiated with favourable clinical response. The present article aimed to emphasise the clinical and histological differential diagnosis and share the treatment experience.<\/jats:p>","DOI":"10.1136\/bcr-2020-239244","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T22:57:06Z","timestamp":1612479426000},"page":"e239244","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Cutaneous Rosai\u2013Dorfman disease: a challenging diagnosis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-643X","authenticated-orcid":false,"given":"Rita","family":"Sampaio","sequence":"first","affiliation":[{"name":"Surgical Pathology Department, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Silva","sequence":"additional","affiliation":[{"name":"Dermatology Department, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goreti","family":"Catorze","sequence":"additional","affiliation":[{"name":"Dermatology Department, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Viana","sequence":"additional","affiliation":[{"name":"Dermatology Department, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"2025082710405036000_14.2.e239244.1","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathologic entity","volume":"87","author":"Rosai","year":"1969","journal-title":"ArchPathol"},{"key":"2025082710405036000_14.2.e239244.2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.anndiagpath.2019.02.004","article-title":"A comprehensive assessment of cutaneous Rosai-Dorfman disease","volume":"40","author":"Ahmed","year":"2019","journal-title":"Ann Diagn Pathol"},{"key":"2025082710405036000_14.2.e239244.3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2141.1995.tb05313.x","article-title":"Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)","volume":"91","author":"Paulli","year":"1995","journal-title":"Br J Haematol"},{"key":"2025082710405036000_14.2.e239244.4","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2020-206733"},{"key":"2025082710405036000_14.2.e239244.5","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200210000-00001"},{"key":"2025082710405036000_14.2.e239244.6","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2019-231927","article-title":"Rosai-Dorfman disease with cutaneous plaques and autoimmune haemolytic anemia","volume":"12","author":"Subhadarshani","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025082710405036000_14.2.e239244.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2012-006723","article-title":"Rosai Dorfman disease: appearances can be deceptive","volume":"2012","author":"Rajasekharan","year":"2012","journal-title":"BMJ Case Rep"},{"key":"2025082710405036000_14.2.e239244.8","first-page":"34","article-title":"Cutaneous Rosai-Dorfman disease persisting after surgical excision: report of a case treated with acitretin","volume":"3","author":"Fening","year":"2010","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:40:57Z","timestamp":1756316457000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,4]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-239244"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239244","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}