{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:55:53Z","timestamp":1756378553547,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,11]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Carney Complex (CNC) is a rare syndrome characterised by skin pigmentation, endocrine over activity and myxomas, with the median age of detection being 20 years. We present a case of CNC diagnosed in infancy after being noted to have multiple lentigines over his face, abdomen, back and thighs at birth. We consider the differential diagnoses of similar cutaneous presentations in the well neonate and review the prognosis and suggested surveillance of patients with CNC.<\/jats:p>","DOI":"10.1136\/bcr-2020-239259","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T14:33:31Z","timestamp":1610030011000},"page":"e239259","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Newborn infant with congenital lentigines as a manifestation of Carney Complex"],"prefix":"10.1136","volume":"14","author":[{"given":"Amarpal Singh","family":"Bilkhu","sequence":"first","affiliation":[{"name":"ScotSTAR Neonatal Transport Service, NHS Greater Glasgow and Clyde, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Sunderesan","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Ayrshire Maternity Unit, University Hospital Crosshouse, Kilmarnock, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2025082801180869000_14.1.e239259.1","doi-asserted-by":"crossref","unstructured":"Mann MW , Weller RB , Hunter HJA . Disorders of Pigmentation. In: Mann MW , Weller RB , Hunter HJA , eds. Clinical dermatology. Fifth Edition. West Sussex: John Wiley & Sons, 2015: 274.","DOI":"10.1002\/9781118938164"},{"key":"2025082801180869000_14.1.e239259.2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.017806"},{"key":"2025082801180869000_14.1.e239259.3","unstructured":"Price HN , Marghoob AA . Disorders of hyperpigmentation and melanocytes. In: Eichenfield LF , Frieden IJ , Zaenglein A , eds. Neonatal and infant dermatology. 3rd edn. London: Elsevier Saunders, 2015: 399\u2013401."},{"key":"2025082801180869000_14.1.e239259.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9446-x"},{"key":"2025082801180869000_14.1.e239259.5","unstructured":"Jones KL , Jones MC , del Campo M . Smith\u2019s Recognizable Patterns of Human Malformation. 7th Edition. Philadelphia: Elsevier Saunders, 2013: 684\u20135."},{"key":"2025082801180869000_14.1.e239259.6","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1969.02100030654006"},{"key":"2025082801180869000_14.1.e239259.7","unstructured":"Jones KL , Jones MC , del Campo M . Smith\u2019s Recognizable Patterns of Human Malformation. 7th Edition. Philadelphia: Elsevier Saunders, 2013: 696\u20137."},{"key":"2025082801180869000_14.1.e239259.8","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0209"},{"key":"2025082801180869000_14.1.e239259.9","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660190068018"},{"key":"2025082801180869000_14.1.e239259.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70244-8"},{"key":"2025082801180869000_14.1.e239259.11","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198507000-00007"},{"key":"2025082801180869000_14.1.e239259.12","unstructured":"National Institue of child health and human development. PRKAR1A mutation database. Available: https:\/\/prkar1a.nichd.nih.gov\/hmdb\/mutations.html [Accessed 6 Jul 2020]."},{"key":"2025082801180869000_14.1.e239259.13","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/jc.2008-2333","article-title":"Mutations in Regulatory Subunit Type 1A of Cyclic Adenosine 5\u2032-Monophosphate-Dependent Protein Kinase (PRKAR1A): Phenotype Analysis in 353 Patients and 80 Different Genotypes","volume":"94","author":"Bertherat","year":"2009","journal-title":"J ClinEndocrinolMetab"},{"key":"2025082801180869000_14.1.e239259.14","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328355a279"},{"key":"2025082801180869000_14.1.e239259.15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4041"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:18:19Z","timestamp":1756369099000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,7]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-239259"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239259","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}