{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:10:25Z","timestamp":1756365025930,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Squamous cell carcinoma (SCC) of the lip typically has a good prognosis when diagnosed at an early stage and treated properly. We present a 65-year-old man with a 3-month history of an ulcerative lesion of the lower lip. On physical examination, he had an ulceration of approximately 5\u00d75\u2009cm in the mucosa of the lower lip, extending through 50% of the lip, and multiple mandibular and neck lymph nodes. The biopsy confirmed SCC of the lip. Surgical treatment was recommended, but the patient was lost to follow-up. The patient eventually returned to the hospital for medical treatment. However, the physical examination, and the images obtained showed progression of the disease. Chemotherapy was started with improvement in the primary site, but he then developed a large submental mass compatible with SCC. The tumour was considered incurable at that time. Palliative radiation therapy was offered; however, he refused any further procedures or treatment.<\/jats:p>","DOI":"10.1136\/bcr-2020-239281","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:14:59Z","timestamp":1678752899000},"page":"e239281","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Aggressive squamous cell carcinoma of the lip"],"prefix":"10.1136","volume":"13","author":[{"given":"Jack","family":"Schnur","sequence":"first","affiliation":[{"name":"Internal Medicine, Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E","family":"Johnson Shaw","sequence":"additional","affiliation":[{"name":"Internal Medicine, Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo R","family":"Carnio","sequence":"additional","affiliation":[{"name":"Internal Medicine, Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Casadesus","sequence":"additional","affiliation":[{"name":"Internal Medicine, Jackson Memorial Hospital, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"2025082723342574000_13.12.e239281.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"2025082723342574000_13.12.e239281.2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/jamadermatol.2015.4994","article-title":"Risk factors for cutaneous squamous cell carcinoma recurrence, metastasis, and disease-specific death: a systematic review and meta-analysis","volume":"152","author":"Thompson","year":"2016","journal-title":"JAMA Dermatol"},{"key":"2025082723342574000_13.12.e239281.3","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1007\/s00405-014-3415-6","article-title":"Squamous cell carcinoma of the lip: survival analysis with long-term follow-up","volume":"272","author":"Ozturk","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2025082723342574000_13.12.e239281.4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/hed.23869","article-title":"Improved overall survival and mortality in head and neck cancer with adjuvant concurrent chemoradiotherapy in national databases","volume":"38","author":"Lin","year":"2016","journal-title":"Head Neck"},{"key":"2025082723342574000_13.12.e239281.5","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21343"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:34:34Z","timestamp":1756362874000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":5,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,17]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1136\/bcr-2020-239281"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239281","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}