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Overuse of zinc-containing denture cream was the cause of excess zinc ingestion and resultant copper deficiency, leading to blood dyscrasia and myelopathy. The cream was withdrawn and intravenous and then oral copper supplementation was implemented. Direct questions with regard to excess zinc in the diet and serological testing of copper and zinc should be considered in any patient with a dorsal column syndrome, particularly with concurrent anaemia. Copper deficiency may also have a role in exacerbating pre-existing cognitive impairment.<\/jats:p>","DOI":"10.1136\/bcr-2020-239375","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T12:55:47Z","timestamp":1626872147000},"page":"e239375","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Hypocupraemia-induced anaemia, sensory ataxia and cognitive impairment secondary to zinc-containing dental adhesive"],"prefix":"10.1136","volume":"14","author":[{"given":"Rayyan","family":"Jamal","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Walid","family":"Dihmis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-2393","authenticated-orcid":false,"given":"Liam Stuart","family":"Carroll","sequence":"additional","affiliation":[{"name":"Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Pengas","sequence":"additional","affiliation":[{"name":"Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"2025082801114784000_14.7.e239375.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ejh.12020","article-title":"Hypocupremia associated cytopenia and myelopathy: a national retrospective review","volume":"90","author":"Gabreyes","year":"2013","journal-title":"Eur J Haematol"},{"key":"2025082801114784000_14.7.e239375.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5511-x"},{"key":"2025082801114784000_14.7.e239375.3","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1005"},{"key":"2025082801114784000_14.7.e239375.4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3233\/JAD-2005-8103","article-title":"Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease","volume":"8","author":"Pajonk","year":"2005","journal-title":"J Alzheimers Dis"},{"key":"2025082801114784000_14.7.e239375.5","doi-asserted-by":"crossref","DOI":"10.1177\/1759091416651511","article-title":"Zinc in multiple sclerosis: a systematic review and meta-analysis","volume":"8","author":"Bredholt","year":"2016","journal-title":"ASN Neuro"},{"key":"2025082801114784000_14.7.e239375.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.046987"},{"key":"2025082801114784000_14.7.e239375.7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1179\/2045772314Y.0000000268","article-title":"Copper deficiency myelopathy: a report of two cases","volume":"38","author":"Plantone","year":"2015","journal-title":"J Spinal Cord Med"},{"key":"2025082801114784000_14.7.e239375.8","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460217"},{"key":"2025082801114784000_14.7.e239375.9","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-219802","article-title":"Zinc containing dental fixative causing copper deficiency myelopathy","volume":"2017","author":"Carroll","year":"2017","journal-title":"BMJ Case Rep"},{"key":"2025082801114784000_14.7.e239375.10","unstructured":"Fixodent.co.uk . 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