{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:06:42Z","timestamp":1756339602879,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,19]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>We report two cases highlighting the role of fluorine-18-fluorodeoxyglucose positron emission tomography\/computerised tomography (18F FDG PET\/CT) in the diagnostic and preoperative workup of indeterminate adrenal masses. Case 1: a 60-year-old man was diagnosed with a large left-sided adrenal mass with indeterminate radiological characteristics on CT. Biochemical investigations ruled out tumour hypersecretion. 18F FDG PET\/CT was performed to exclude metastases and identified a pulmonary nodule in the left upper lobe. Histology of the resected adrenal tumour demonstrated a secondary metastasis from an adenocarcinoma of the lung. Case 2: an 88-year-old male was found to have a heterogeneous and vascular left-sided suprarenal mass and a smaller right-sided adrenal nodule. Both adrenal nodules had indeterminate radiological characteristics. Biochemical investigations were negative. PET\/CT demonstrated high avidity in the bilateral adrenal nodules but no extra-adrenal FDG avid disease. Histology demonstrated a metastatic carcinoma of pulmonary origin.<\/jats:p>","DOI":"10.1136\/bcr-2020-239463","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T11:36:27Z","timestamp":1613993787000},"page":"e239463","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Large adrenal mass heralding the diagnosis of occult extra-adrenal malignancy in two patients"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-3382","authenticated-orcid":false,"given":"James","family":"Anderton","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios","family":"Ghobrial","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilis","family":"Kosmoliaptsis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"2025082712451147000_14.2.e239463.1","doi-asserted-by":"crossref","unstructured":"Francis I , Mayo-Smith W . 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