{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:27:09Z","timestamp":1787621229244,"version":"build-2736575974"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,23]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>An early-term infant with uncomplicated perinatal history was found to have a large thrombus in the aortic arch after he failed regular newborn critical congenital heart defect screen. He responded well to bivalirudin thrombolytic and tissue-plasminogen activator (tPA) combination therapy, with a significant resolution of the thrombus. The infant tolerated hospital admission well with no significant complications. He was discharged home on daily aspirin at 2\u2009weeks of life. To our knowledge, the combination therapy approach with bivalirudin and tPA is the first one reported in the literature in the neonatal age group.<\/jats:p>","DOI":"10.1136\/bcr-2020-239535","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T12:38:20Z","timestamp":1610973500000},"page":"e239535","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Bivalirudin and thrombolytic therapy: a novel successful treatment of severe aortic arch thrombosis in a term neonate"],"prefix":"10.1136","volume":"14","author":[{"given":"Amjad","family":"Taha","sequence":"first","affiliation":[{"name":"Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan","family":"Rajgarhia","sequence":"additional","affiliation":[{"name":"Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, USA"},{"name":"Pediatrics, University of Missouri Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-2963","authenticated-orcid":false,"given":"Mahdi","family":"Alsaleem","sequence":"additional","affiliation":[{"name":"Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, USA"},{"name":"Department of Pediatrics, University of Kansas School of Medicine Wichita, Wichita, Kansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2025082703222695000_14.1.e239535.1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s00246-019-02068-5","article-title":"In utero aortic arch thrombosis masquerading as interrupted aortic arch: a case report and review of the literature","volume":"40","author":"Knadler","year":"2019","journal-title":"Pediatr Cardiol"},{"key":"2025082703222695000_14.1.e239535.2","doi-asserted-by":"crossref","DOI":"10.1017\/S1047951112002077","article-title":"Neonatal aortic arch thrombosis: analysis of thrombophilic risk factors and prognosis","volume":"24","author":"Wieland","year":"2014","journal-title":"Cardiol Young"},{"key":"2025082703222695000_14.1.e239535.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.6.e114"},{"key":"2025082703222695000_14.1.e239535.4","first-page":"1016","article-title":"Neonatal aortic thrombosis associated with the lupus anticoagulant","volume":"71","author":"Sheridan-Pereira","year":"1988","journal-title":"Obstet Gynecol"},{"key":"2025082703222695000_14.1.e239535.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2006.00007.x"},{"key":"2025082703222695000_14.1.e239535.6","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181a6e030"},{"key":"2025082703222695000_14.1.e239535.7","article-title":"Successful surgical management of aortic arch thrombosis in the neonate","author":"Williams","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"2025082703222695000_14.1.e239535.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02623.x"},{"key":"2025082703222695000_14.1.e239535.9","first-page":"108","article-title":"Bivalirudin use in an infant with persistent clotting on unfractionated heparin","volume":"16","author":"Malloy","year":"2011","journal-title":"J Pediatr Pharmacol Ther"},{"key":"2025082703222695000_14.1.e239535.10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.thromres.2018.05.009","article-title":"Anticoagulation during ECMO in neonatal and paediatric patients","volume":"173","author":"Barton","year":"2019","journal-title":"Thromb Res"},{"key":"2025082703222695000_14.1.e239535.11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1527-3466.2005.tb00177.x","article-title":"Bivalirudin: pharmacology and clinical applications","volume":"23","author":"Shammas","year":"2005","journal-title":"Cardiovasc Drug Rev"},{"key":"2025082703222695000_14.1.e239535.12","doi-asserted-by":"publisher","DOI":"10.1136\/fn.85.1.F18"},{"key":"2025082703222695000_14.1.e239535.13","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28094","article-title":"Bivalirudin during thrombolysis with catheter-directed tPA in a heparin-refractory patient: a case report","volume":"67","author":"Regling","year":"2020","journal-title":"Pediatr Blood Cancer"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:22:33Z","timestamp":1756290153000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-239535"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239535","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}