{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:10:18Z","timestamp":1756379418400,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,2,16]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Deep vein thrombosis has been recognised as a complication of antipsychotic treatment and is reported to be more common with atypical antipsychotics. Risperidone is a second-generation atypical antipsychotic and there have been case reports of risperidone-associated deep vein thrombosis, most of them reporting the complication from 2\u2009weeks to a few months of initiation of therapy. Here, we are reporting a case of deep vein thrombosis in a male patient in his early forties with paranoid schizophrenia, which presented on the fourth day of starting risperidone therapy. This case is being reported to highlight the fact that deep vein thrombosis can occur as early as fourth day of initiation of risperidone therapy, that too at a low dose (2\u2009mg\/day). The case also emphasises the importance of monitoring these patients for this rare but potentially serious adverse effect from the first day itself after initiation of a new antipsychotic.<\/jats:p>","DOI":"10.1136\/bcr-2020-239569","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T14:45:31Z","timestamp":1614955531000},"page":"e239569","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Deep vein thrombosis on the fourth day of risperidone therapy"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-2484","authenticated-orcid":false,"given":"Kavitha","family":"Konnakkaparambil Ramakrishnan","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Government TD Medical College, Alapuzha, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-532X","authenticated-orcid":false,"given":"Mithila","family":"George","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Government Medical College, Ernakulam, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"2025082803283324000_14.3.e239569.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx003"},{"key":"2025082803283324000_14.3.e239569.2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.179.1.63"},{"key":"2025082803283324000_14.3.e239569.3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/CLEP.S4969","article-title":"Antipsychotics and risk of venous thromboembolism: a population-based case-control study","volume":"1","author":"J\u00f6nsson","year":"2009","journal-title":"Clin Epidemiol"},{"key":"2025082803283324000_14.3.e239569.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02784-7"},{"key":"2025082803283324000_14.3.e239569.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4245"},{"key":"2025082803283324000_14.3.e239569.6","first-page":"765","article-title":"Antipsychotic-Induced venous thromboembolism","volume":"16","author":"H\u00e4gg","year":"2002","journal-title":"Mol Diag Ther"},{"key":"2025082803283324000_14.3.e239569.7","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1016\/S0924-9338(13)75933-9","article-title":"Risperidone-associated deep venous thrombosis: case report and review[abstract]","volume":"28","author":"Ouanes","year":"2013","journal-title":"Eur Psychiatry"},{"key":"2025082803283324000_14.3.e239569.8","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2210"},{"key":"2025082803283324000_14.3.e239569.9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2165\/11633920-000000000-00000","article-title":"Venous thromboembolism in recipients of antipsychotics: incidence, mechanisms and management","volume":"26","author":"J\u00f6nsson","year":"2012","journal-title":"CNS Drugs"},{"key":"2025082803283324000_14.3.e239569.10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/2008-2231-20-71","article-title":"Deep venous thrombosis and atypical antipsychotics: three cases report","volume":"20","author":"Sheikhmoonesi","year":"2012","journal-title":"Daru"},{"key":"2025082803283324000_14.3.e239569.11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1160\/TH15-11-0895","article-title":"Use of antipsychotics and risk of venous thromboembolism in postmenopausal women. A population-based nested case-control study","volume":"115","author":"Wang","year":"2016","journal-title":"Thromb Haemost"},{"key":"2025082803283324000_14.3.e239569.12","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025082803283324000_14.3.e239569.13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1108\/MIJ-10-2019-0005","article-title":"Case report: chlorpromazine and deep venous thrombosis","volume":"11","author":"Reed","year":"2019","journal-title":"Ment Illn"},{"key":"2025082803283324000_14.3.e239569.14","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2003.00073.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:28:38Z","timestamp":1756376918000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,5]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1136\/bcr-2020-239569"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239569","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}