{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:32:10Z","timestamp":1791232330082,"version":"4.1.0"},"reference-count":8,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,27]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>We report a case of severe hypercalcaemia secondary to rhabdomyolysis in a woman with COVID-19 (SARS CoV-2) infection. The patient presented with myalgia and anuria with an acute kidney injury requiring haemodialysis. Creatine kinase peaked at 760\u2009000\u2009IU\/L. A biphasic calcaemic response was observed with initial severe hypocalcaemia followed by severe, symptomatic hypercalcaemia, persistent despite haemodialysis. Control of the calcium levels was achieved by continuous haemofiltration.<\/jats:p>","DOI":"10.1136\/bcr-2020-239611","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:55:50Z","timestamp":1621857350000},"page":"e239611","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Rhabdomyolysis and severe biphasic disturbance of calcium homeostasis secondary to COVID-19 infection"],"prefix":"10.1136","volume":"14","author":[{"given":"Adrian Po Zhu","family":"Li","sequence":"first","affiliation":[{"name":"Diabetes and Endocrinology, Guy's and St Thomas' Hospitals NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Thomas","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, Guy's and St Thomas' Hospitals NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refik","family":"Gokmen","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, Guy's and St Thomas' Hospitals NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulmini","family":"Kariyawasam","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, Guy's and St Thomas' Hospitals NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"2025082700580118000_14.5.e239611.1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-236719","article-title":"Rhabdomyolysis as an initial presentation in a patient diagnosed with COVID-19","volume":"13","author":"Valente-Acosta","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2025082700580118000_14.5.e239611.2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1181553"},{"key":"2025082700580118000_14.5.e239611.3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.12659\/AJCR.891046","article-title":"Severe hypercalcemia complicating recovery of acute kidney injury due to rhabdomyolysis","volume":"15","author":"Hechanova","year":"2014","journal-title":"Am J Case Rep"},{"key":"2025082700580118000_14.5.e239611.4","first-page":"257","article-title":"Bone scintigraphy of severe hypercalcemia following simvastatin induced rhabdomyolysis","volume":"13","author":"Mirza","year":"2016","journal-title":"Clin Cases Miner Bone Metab"},{"key":"2025082700580118000_14.5.e239611.5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5847\/wjem.j.issn.1920-8642.2012.01.002","article-title":"Rhabdomyolosis and its pathogenesis","volume":"3","author":"Zhang","year":"2012","journal-title":"World J Emerg Med"},{"key":"2025082700580118000_14.5.e239611.6","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-1-137"},{"key":"2025082700580118000_14.5.e239611.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-223772","article-title":"Treatment of extreme hypercalcaemia: the role of haemodialysis","volume":"2018","author":"Basok","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082700580118000_14.5.e239611.8","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1046\/j.1523-1755.56.s.72.3.x","article-title":"Is there a role of continuous renal replacement therapies in patients with liver and renal failure?","volume":"56","author":"Davenport","year":"1999","journal-title":"Kidney International"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:58:06Z","timestamp":1756281486000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,24]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2020-239611"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239611","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}