{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:58:21Z","timestamp":1762981101475,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,20]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Mitral valve prolapse is a common finding in Graves\u2019 disease. However, severe mitral regurgitation (MR) is a relatively uncommon manifestation of Graves\u2019 disease. We report a case of a 32-year-old woman with toxic Graves\u2019 disease and MR. The echocardiogram was suggestive of severe MR with biventricular failure, severe enough to be considered for mitral valve replacement. With medical control of the thyrotoxic state, a repeat echocardiogram revealed only trace MR, with normal left ventricular function. The timely management of the thyrotoxic state in this patient with Graves\u2019 disease and moderate to severe MR possibly related to myxomatous degeneration, averted the need for mitral valve replacement.<\/jats:p>","DOI":"10.1136\/bcr-2020-239626","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T23:53:46Z","timestamp":1612482826000},"page":"e239626","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Reversible, severe mitral regurgitation in thyrotoxic Graves\u2019 disease"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-8287","authenticated-orcid":false,"given":"Kaveh","family":"Fekri","sequence":"first","affiliation":[{"name":"Internal Medicine, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Maud","family":"Michel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tamilia","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Sir Mortimer B Davis Jewish General Hospital, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"2025082803211019000_14.2.e239626.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.08.018"},{"key":"2025082803211019000_14.2.e239626.2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1210\/js.2018-00173","article-title":"Severe mitral regurgitation as a result of rupture of mitral valve chordae tendineae in a patient with Graves disease","volume":"2","author":"Karashima","year":"2018","journal-title":"J Endocr Soc"},{"key":"2025082803211019000_14.2.e239626.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198108273050906"},{"key":"2025082803211019000_14.2.e239626.4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.7326\/0003-4819-102-4-479","article-title":"Chronic thyroiditis and mitral valve prolapse","volume":"102","author":"Marks","year":"1985","journal-title":"Ann Intern Med"},{"key":"2025082803211019000_14.2.e239626.5","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1971.02110060114022"},{"key":"2025082803211019000_14.2.e239626.6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.14740\/cr564w","article-title":"Thyrotoxic valvulopathy: case report and review of the literature","volume":"8","author":"Pierre","year":"2017","journal-title":"Cardiol Res"},{"key":"2025082803211019000_14.2.e239626.7","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0033"},{"key":"2025082803211019000_14.2.e239626.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.105"},{"key":"2025082803211019000_14.2.e239626.9","first-page":"e4","article-title":"Flail mitral valve: a rare complication of a thyroid storm","volume":"5","author":"Chen","year":"2019","journal-title":"AACE Clin Case Rep"},{"key":"2025082803211019000_14.2.e239626.10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0002-9629(15)41663-5","article-title":"Case report: reversible mitral regurgitation and congestive heart failure complicating thyrotoxicosis","volume":"311","author":"Cavros","year":"1996","journal-title":"Am J Med Sci"},{"key":"2025082803211019000_14.2.e239626.11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0002-9149(87)90959-3","article-title":"Spontaneous rupture of mitral chordae tendineae in hyperthyroidism","volume":"59","author":"Aronson","year":"1987","journal-title":"Am J Cardiol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:21:19Z","timestamp":1756376479000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,4]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-239626"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239626","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}