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We report a case of a patient who developed acute respiratory distress syndrome (ARDS) with features suggestive of transfusion-related acute lung injury after being treated with convalescent plasma for COVID-19. We emphasise the need to be aware of the potential risk of transfusion reactions and disease worsening with convalescent plasma administration and to weigh the risk and benefits of this therapy before administration to patients and propose that further study be done regarding the potential risks of convalescent plasma.<\/jats:p>","DOI":"10.1136\/bcr-2020-239762","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T13:25:34Z","timestamp":1611840334000},"page":"e239762","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Convalescent plasma for COVID-19 complicated by ARDS due to TRALI"],"prefix":"10.1136","volume":"14","author":[{"given":"Kevin Y","family":"Wang","sequence":"first","affiliation":[{"name":"Internal Medicine, Northwell Health, Great Neck, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik","family":"Shah","sequence":"additional","affiliation":[{"name":"Internal Medicine, Northwell Health, Great Neck, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Pierce","sequence":"additional","affiliation":[{"name":"Internal Medicine, Northwell Health, Great Neck, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"2025082804002415000_14.1.e239762.1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02926-2"},{"key":"2025082804002415000_14.1.e239762.2","first-page":"1","article-title":"The role of passive immunization in the age of SARS-CoV-2: an update","volume":"25","author":"Fischer","year":"2020","journal-title":"Eur J Med Res"},{"key":"2025082804002415000_14.1.e239762.3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1172\/JCI138003","article-title":"The convalescent sera option for containing COVID-19","volume":"130","author":"Casadevall","year":"2020","journal-title":"J Clin Invest"},{"key":"2025082804002415000_14.1.e239762.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-8-200610170-00139"},{"key":"2025082804002415000_14.1.e239762.5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq106"},{"key":"2025082804002415000_14.1.e239762.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.11.009"},{"key":"2025082804002415000_14.1.e239762.7","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu396"},{"key":"2025082804002415000_14.1.e239762.8","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S2213-2600(15)00180-0","article-title":"Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease contracted in Madrid, Spain","volume":"3","author":"Mora-Rillo","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2025082804002415000_14.1.e239762.9","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2016.36.4.393"},{"key":"2025082804002415000_14.1.e239762.10","unstructured":"Stroncek D . TRALI pathophysiology."},{"key":"2025082804002415000_14.1.e239762.11","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.200642"},{"key":"2025082804002415000_14.1.e239762.12","article-title":"Treatment of COVID-19 patients with convalescent plasma in Houston, Texas","author":"Salazar","year":"2020","journal-title":"medRxiv"},{"key":"2025082804002415000_14.1.e239762.13","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/jmv.25882","article-title":"Treatment with convalescent plasma for COVID-19 patients in Wuhan, China","volume":"92","author":"Ye","year":"2020","journal-title":"J Med Virol"},{"key":"2025082804002415000_14.1.e239762.14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.478"},{"key":"2025082804002415000_14.1.e239762.15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ccell.2012.06.005","article-title":"Pulmonary complications of transfused blood components","volume":"24","author":"Benson","year":"2012","journal-title":"Crit Care Nurs Clin North Am"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:00:38Z","timestamp":1756378838000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-239762"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239762","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}