{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:56:30Z","timestamp":1760028990460,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,17]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>A 31-year-old G3P2002 with history of two prior caesarean sections presented with influenza-like illness, requiring intubation secondary to acute respiratory distress syndrome. Investigations revealed intrauterine fetal demise at 30-week gestation.<\/jats:p>\n               <jats:p>She soon deteriorated with sepsis and multiple organs impacted. Risks of the gravid uterus impairing cardiopulmonary function appeared greater than risks of delivery, including that of uterine rupture. Vaginal birth after caesarean was achieved with misoprostol and critical care status rapidly improved.<\/jats:p>\n               <jats:p>Current guidelines for management of fetal demise in patients with prior hysterotomies are mixed: although the American College of Obstetricians and Gynecologists recommends standard obstetric protocols rather than misoprostol administration for labour augmentation, there is limited published data citing severe maternal morbidity associated with misoprostol use. This case report argues misoprostol-augmented induction of labour can be a reasonable option in a medically complex patient with fetal demise and prior hysterotomies.<\/jats:p>","DOI":"10.1136\/bcr-2020-239872","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T11:16:13Z","timestamp":1611918973000},"page":"e239872","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Misoprostol-augmented induction of labour for third trimester fetal demise in a patient with prior hysterotomies"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-836X","authenticated-orcid":false,"given":"Isabel","family":"Beshar","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Thomson","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynecology, Santa Clara Valley Medical Center, San Jose, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Byrne","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, Obstetrics and Gynecology, Santa Clara Valley Medical Center, San Jose, California, USA"},{"name":"Maternal Fetal Medicine, Obstetrics & Gynecology, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"2025082700535696000_14.1.e239872.1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1055\/s-0030-1254548","article-title":"Mode of delivery in women with antepartum fetal death and prior cesarean delivery","volume":"27","author":"Ramirez","year":"2010","journal-title":"Am J Perinatol"},{"key":"2025082700535696000_14.1.e239872.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)80019-6"},{"key":"2025082700535696000_14.1.e239872.3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000292602","article-title":"Late vaginal induced abortion after a previous cesarean birth: potential for uterine rupture","volume":"36","author":"Boulot","year":"1993","journal-title":"Gynecol Obstet Invest"},{"key":"2025082700535696000_14.1.e239872.4","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1097\/AOG.0000000000003719","article-title":"Obstetric care consensus: management of stillbirth delivery","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2025082700535696000_14.1.e239872.5","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/GRF.0000000000000067","article-title":"ARDS in pregnancy","volume":"57","author":"Duarte","year":"2014","journal-title":"Clin Obstet Gynecol"},{"key":"2025082700535696000_14.1.e239872.6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/AOG.0000000000001907","article-title":"Acute respiratory distress syndrome in pregnant women","volume":"129","author":"Rush","year":"2017","journal-title":"Obstet Gynecol"},{"key":"2025082700535696000_14.1.e239872.7","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.562569"},{"key":"2025082700535696000_14.1.e239872.8","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000259312.36053.02"},{"key":"2025082700535696000_14.1.e239872.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.09.010"},{"key":"2025082700535696000_14.1.e239872.10","first-page":"1","article-title":"Vaginal birth after cesarean: new insights","author":"Guise","year":"2010","journal-title":"Evid Rep Technol Assess"},{"key":"2025082700535696000_14.1.e239872.11","first-page":"168","article-title":"Clinical management guidelines for obstetrician \u2013 Gynecologists","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"2025082700535696000_14.1.e239872.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450101"},{"key":"2025082700535696000_14.1.e239872.13","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200608000-00045"},{"key":"2025082700535696000_14.1.e239872.14","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1055\/s-0035-1558171","article-title":"Misoprostol for Labour Induction after Previous Caesarean Section \u2013 Forever a \u201cNo Go\u201d?","volume":"75","author":"Rath","year":"2015","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"2025082700535696000_14.1.e239872.15","doi-asserted-by":"crossref","unstructured":"Pundir J , Coomarasamy A , Pundir J . Late intrauterine fetal death and stillbirth. Obstet Evidence-Based Algorithms 2016:14\u201318.","DOI":"10.1017\/CBO9781107338876.006"},{"key":"2025082700535696000_14.1.e239872.16","first-page":"157","article-title":"Misoprostol for labor induction in the second trimester in a woman with previous three cesarean deliveries and an intrauterine death of an anencephaly","volume":"40","author":"Rouzi","year":"2013","journal-title":"Clin Exp Obstet Gynecol"},{"key":"2025082700535696000_14.1.e239872.17","first-page":"85","article-title":"Use of misoprostol for pregnancy termination in women with prior classical cesarean delivery: a report of 3 cases","volume":"56","author":"Malapati","year":"2011","journal-title":"J Reprod Med"},{"key":"2025082700535696000_14.1.e239872.18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3109\/01443615.2015.1072808","article-title":"How much misoprostol is safe? - First reported case of second-trimester uterine rupture after a single low dose","volume":"36","author":"Datta","year":"2016","journal-title":"J Obstet Gynaecol"},{"key":"2025082700535696000_14.1.e239872.19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ijgo.12181","article-title":"FIGO\u2019s updated recommendations for misoprostol used alone in gynecology and obstetrics","volume":"138","author":"Morris","year":"2017","journal-title":"Int J Gynecol Obstet"},{"key":"2025082700535696000_14.1.e239872.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01829.x"},{"key":"2025082700535696000_14.1.e239872.21","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1097\/AOG.0000000000001778","article-title":"Mechanical and pharmacologic methods of labor induction: a randomized controlled trial","volume":"128","author":"Levine","year":"2016","journal-title":"Obstet Gynecol"},{"key":"2025082700535696000_14.1.e239872.22","doi-asserted-by":"crossref","first-page":"743.e1","DOI":"10.1016\/j.ajog.2020.05.007","article-title":"Combination of Foley and prostaglandins versus Foley and oxytocin for cervical ripening: a network meta-analysis","volume":"223","author":"Orr","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"2025082700535696000_14.1.e239872.23","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMsb1612526","article-title":"Sixteen years of Overregulation: time to Unburden Mifeprex","volume":"376","author":"Raymond","year":"2017","journal-title":"N Engl J Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:54:05Z","timestamp":1756281245000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,29]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-239872"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239872","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}