{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:45:39Z","timestamp":1769877939115,"version":"3.49.0"},"reference-count":9,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,2,13]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Gorham-Stout disease (GSD) is a rare disorder characterised by massive painless osteolysis due to lymphangiomatous tissue progression. GSD\u2019s pathogenesis is still unclear, but osteoclasts' activation may play a role in its pathogenesis. There are multiple complications associated with GSD. One of the most severe and life-threatening complications is a chylothorax. Herein we discuss a case of a patient with a history of GSD who presented to the hospital with progressive dyspnoea secondary to a large left-sided pleural effusion, which was later confirmed to be a chylothorax. We will further discuss the current literature and treatment of chylothorax associated with GSD.<\/jats:p>","DOI":"10.1136\/bcr-2020-239891","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T11:56:14Z","timestamp":1615377374000},"page":"e239891","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Gorham-Stout disease: interesting cause of pleural effusion"],"prefix":"10.1136","volume":"14","author":[{"given":"Daniel","family":"Olea-Mendoza","sequence":"first","affiliation":[{"name":"Internal Medicine, Cooper University Health Care, Camden, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio Romeo","family":"Terrigno","sequence":"additional","affiliation":[{"name":"Internal Medicine, Cooper University Health Care, Camden, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayobamidele","family":"Balogun","sequence":"additional","affiliation":[{"name":"Internal Medicine, Cooper University Health Care, Camden, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Caprio","sequence":"additional","affiliation":[{"name":"Internal Medicine, Cooper University Health Care, Camden, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"2025082707054587000_14.3.e239891.1","unstructured":"Gorham\u2019s Disease . 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Chylothorax in Gorham\u2019s syndrome","volume":"105","author":"Tie","year":"1994","journal-title":"A common complication of a rare disease. Chest"},{"key":"2025082707054587000_14.3.e239891.7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/LBR.0000000000000506","article-title":"Chylothorax from Gorham-Stout disease","volume":"25","author":"Kotaru","year":"2018","journal-title":"J Bronchology Interv Pulmonol"},{"key":"2025082707054587000_14.3.e239891.8","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90968-2"},{"key":"2025082707054587000_14.3.e239891.9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5090\/kjtcs.2019.52.1.44","article-title":"Chylous manifestations and management of Gorham-Stout syndrome","volume":"52","author":"Cho","year":"2019","journal-title":"Korean J Thorac Cardiovasc Surg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:05:55Z","timestamp":1756303555000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,10]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1136\/bcr-2020-239891"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239891","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}