{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:38:49Z","timestamp":1772217529762,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,6,10]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Ehlers-Danlos syndrome (EDS) is an uncommon heterogenous autosomal dominant multisystemic connective tissue disorder, which may potentially present with life-threatening emergencies. The prevalence of EDS of all subtypes is from 1 in 10 000 to 1 in 20\u2009000. Pregnancy in women with type IV EDS poses significant challenges, necessitating the care of multidisciplinary team. Potential complications of type IV EDS include arterial dissection, arterial aneurysm, visceral rupture, excessive bleeding, tissue fragility and delayed wound healing. We present an interesting case of a pregnant woman with type IV EDS who had previous cerebrovascular complications and had a successful delivery in our tertiary centre following a collaborative approach to her care.<\/jats:p>","DOI":"10.1136\/bcr-2020-239916","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T10:35:20Z","timestamp":1627641320000},"page":"e239916","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Peripartum considerations and challenges in the management of type IV Ehlers-Danlos syndrome"],"prefix":"10.1136","volume":"14","author":[{"given":"Hazarathamma","family":"Makam","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmita","family":"Patwardhan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Darbar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2025082622383455000_14.7.e239916.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.12.005"},{"key":"2025082622383455000_14.7.e239916.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.06994.x"},{"key":"2025082622383455000_14.7.e239916.3","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-2-32","article-title":"Ehlers-Danlos syndrome type IV","volume":"2","author":"Germain","year":"2007","journal-title":"Orphanet J Rare Dis"},{"key":"2025082622383455000_14.7.e239916.4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/1753495X18754577","article-title":"Hypermobile Ehlers-Danlos syndrome and pregnancy","volume":"11","author":"Karthikeyan","year":"2018","journal-title":"Obstet Med"},{"key":"2025082622383455000_14.7.e239916.5","first-page":"974","article-title":"Remote vascular catastrophes after neurovascular Interventional therapy for type 4 Ehlers-Danlos syndrome","volume":"21","author":"Horowitz","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082622383455000_14.7.e239916.6","first-page":"2152","article-title":"Patients with type IV Ehlers-Danlos syndrome may be predisposed to atlantoaxial subluxation","volume":"22","author":"Halko","year":"1995","journal-title":"J Rheumatol"},{"key":"2025082622383455000_14.7.e239916.7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.12968\/bjom.2018.26.4.217","article-title":"Hypermobile Ehlers-Danlos syndrome during pregnancy, birth and beyond","volume":"26","author":"Pezaro","year":"2018","journal-title":"Br J Midwifery"},{"key":"2025082622383455000_14.7.e239916.8","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/ccr3.1639","article-title":"Renal infarction in vascular Ehlers-Danlos syndrome masquerading as pyelonephritis","volume":"6","author":"Dousa","year":"2018","journal-title":"Clin Case Rep"},{"key":"2025082622383455000_14.7.e239916.9","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1002\/ajmg.a.35506","article-title":"Gynecologic and obstetric implications of the joint hypermobility syndrome (a.k.a. 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