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Recently, tumour necrosis factor alpha inhibitors have been implicated in several cases of drug-induced AIH which impact treatment regimens for patients with inflammatory bowel disease (IBD). We present a case of infliximab-induced seronegative AIH responding to budesonide therapy with successful alteration of IBD treatment regimen to vedolizumab.<\/jats:p>","DOI":"10.1136\/bcr-2020-239944","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:55:19Z","timestamp":1621857319000},"page":"e239944","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Infliximab-induced autoimmune hepatitis"],"prefix":"10.1136","volume":"14","author":[{"given":"Alexander","family":"Jenkins","sequence":"first","affiliation":[{"name":"Internal Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Austin","sequence":"additional","affiliation":[{"name":"Pathology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Hughes","sequence":"additional","affiliation":[{"name":"Internal Medicine, Naval Medical Center San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Sadowski","sequence":"additional","affiliation":[{"name":"Gastroenterology, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Torres","sequence":"additional","affiliation":[{"name":"Gastroenterology, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"2025082803124315000_14.5.e239944.1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/MPG.0000000000001137","article-title":"Infliximab-associated immunomediated hepatitis in children with inflammatory bowel disease","volume":"63","author":"Mostamand","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025082803124315000_14.5.e239944.2","unstructured":"Hoofnagle JH . LiverTox [revised 2015 January, Internet.]. Bethesda, MD: U.S. National Library of Medicine, National Institutes of Health, U.S. Department of Health & Human Services, 1993. 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