{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:14:52Z","timestamp":1790914492199,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,19]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Neonatal diabetes (NDM) is defined as diabetes that occurs in the first 6 months of life, the majority of cases are due to sporadic mutations. ATP-sensitive potassium channels located in the beta cells of the pancreas play a major role in insulin secretion and blood glucose homeostasis. Mutations that alter the function of these channels may lead to NDM. We report a case of a 26-year-old Irish woman who was diagnosed with NDM at the age of 4\u2009weeks and treated as type 1 diabetes mellitus, with multiple daily injections of insulin with suboptimal glycaemic control and frequent episodes of hypoglycaemic. She underwent genetic testing for NDM and was diagnosed with a KCNJ11 gene mutation. She was transitioned to high dose glibenclamide at the age of 16 years, but the trial failed due to poor glycaemic control and patient preference, and she was restarted on insulin. At 24 years of age, she was successfully transitioned from insulin (total daily dose 50 units) to high dose sulfonylurea (SU) (glibenclamide 15\u2009mg twice daily). This resulted in optimal control of blood glucose (HbA1C fell from 63 to 44\u2009mmol\/mol), lower rates of hypoglycaemic and better quality of life. This case demonstrates that a second trial of SU in later life may be successful.<\/jats:p>","DOI":"10.1136\/bcr-2020-239973","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T12:41:45Z","timestamp":1617972105000},"page":"e239973","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Successful transition from insulin to sulfonylurea, on second attempt, in a 24-year-old female with neonatal diabetes secondary to KCNJ11 gene mutation"],"prefix":"10.1136","volume":"14","author":[{"given":"Sulaiman","family":"Hajji","sequence":"first","affiliation":[{"name":"Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Aljenaee","sequence":"additional","affiliation":[{"name":"Endocrine and Diabetes, Saint James's Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Garrahy","sequence":"additional","affiliation":[{"name":"Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Byrne","sequence":"additional","affiliation":[{"name":"Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"2025082703542088000_14.4.e239973.1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.2040-1124.2011.00106.x","article-title":"Genetics and pathophysiology of neonatal diabetes mellitus","volume":"2","author":"Naylor","year":"2011","journal-title":"J Diabetes Investig"},{"key":"2025082703542088000_14.4.e239973.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061759"},{"key":"2025082703542088000_14.4.e239973.3","doi-asserted-by":"publisher","DOI":"10.1002\/iub.246"},{"key":"2025082703542088000_14.4.e239973.4","first-page":"2821","article-title":"Case Report: Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11 -related Diabetes","volume":"102","author":"Greeley","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082703542088000_14.4.e239973.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032922"},{"key":"2025082703542088000_14.4.e239973.6","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1007\/s00125-015-3593-9","article-title":"Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes","volume":"58","author":"Thurber","year":"2015","journal-title":"Diabetologia"},{"key":"2025082703542088000_14.4.e239973.7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1206"},{"key":"2025082703542088000_14.4.e239973.8","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1628"},{"key":"2025082703542088000_14.4.e239973.9","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1007\/s00125-016-3921-8","article-title":"Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes","volume":"59","author":"Babiker","year":"2016","journal-title":"Diabetologia"},{"key":"2025082703542088000_14.4.e239973.10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/2230-8210.155402","article-title":"Puberty and type 1 diabetes","volume":"19","author":"Chowdhury","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"key":"2025082703542088000_14.4.e239973.11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S2213-8587(18)30106-2","article-title":"Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study","volume":"6","author":"Bowman","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2025082703542088000_14.4.e239973.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000721"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-239973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:54:29Z","timestamp":1756292069000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-239973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,9]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2020-239973"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-239973","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}