{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T04:36:25Z","timestamp":1763958985540,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,2,7]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>IgG4-related disease is a rheumatological disorder, affecting multiple organ systems, and displaying dense lymphoplasmacytic inflammatory infiltrate and storiform fibrosis on histology. The pulmonary manifestations of IgG4-related disease are varied. Most commonly, bronchovascular consolidation and perilymphatic parenchymal thickening occur. IgG4-related disease can present as a solitary parenchymal mass and is often mistaken for a primary pulmonary or haematological malignancy. This report presents a case of IgG4-related disease in a patient with 6 months reported haemoptysis symptomatology and CT findings of perihilar lymphadenopathy, multiple pulmonary parenchymal nodules and a single parenchymal mass. Clinician cognisance of the histopathological presentation of IgG4-disease is important. It should be considered as a differential in patients for which investigations have ruled out malignancy, as it is responsive to glucocorticoids in the majority of cases.<\/jats:p>","DOI":"10.1136\/bcr-2020-239976","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T10:59:51Z","timestamp":1614077991000},"page":"e239976","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["IgG4-related disease: a great mimicker of lung cancer"],"prefix":"10.1136","volume":"14","author":[{"given":"Natalie Louise","family":"Simon","sequence":"first","affiliation":[{"name":"Respiratory Medicine Department, Bedford Hospital, Bedfordshire Hospitals NHS Foundation Trust, Bedford, Bedfordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Negmeldin","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department, Bedford Hospital, Bedfordshire Hospitals NHS Foundation Trust, Bedford, Bedfordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Matsui S . 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A case of marginal zone B cell lymphoma mimicking IgG4-related Dacryoadenitis and sialoadenitis. World J Surg Oncol 2015.","key":"2025082701435993000_14.2.e239976.12","DOI":"10.1186\/s12957-015-0459-z"},{"doi-asserted-by":"crossref","unstructured":"Wallace ZS , Deshpande V , Mattoo H , et al . Igg4-Related disease: clinical and laboratory features in one hundred twenty-five patients. Arthritis Rheumatol 2015.","key":"2025082701435993000_14.2.e239976.13","DOI":"10.1002\/art.39205"},{"doi-asserted-by":"crossref","unstructured":"Carruthers MN , Khosroshahi A , Augustin T , et al . The diagnostic utility of serum IgG4 concentrations in IgG4-related disease. Ann Rheum Dis 2015.","key":"2025082701435993000_14.2.e239976.14","DOI":"10.1136\/annrheumdis-2013-204907"},{"doi-asserted-by":"crossref","unstructured":"Wallace ZS , Mattoo H , Carruthers M , et al . Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations. 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