{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:10Z","timestamp":1756339390582,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,15]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder belonging to the family of transmissible spongiform encephalopathies. The disease is believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. Our patient is an 84-year-old Caucasian man who presented to the geriatric clinic for evaluation of short-term memory loss and decreased concentration which started 3 months prior to initial evaluation. Rapid progression of dementia demonstrated by severe impairment in tasks with a predominantly visual component, including visual scanning, perceptual reasoning and visual spatial processing. Diagnosis of CJD was determined by characteristic ribboning on brain MRI as well as notable real-time quaking-induced conversion on cerebrospinal fluid.<\/jats:p>","DOI":"10.1136\/bcr-2020-240020","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T12:45:28Z","timestamp":1620737128000},"page":"e240020","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Creutzfeldt-Jakob disease as a cause of dementia"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-0135","authenticated-orcid":false,"given":"Rasha","family":"Nakhleh","sequence":"first","affiliation":[{"name":"Internal Medicine and Geriatrics, Oregon Health and Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-8277","authenticated-orcid":false,"given":"Sophia Tenaye","family":"Tessema","sequence":"additional","affiliation":[{"name":"College of Human Medicine, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-7202","authenticated-orcid":false,"given":"Abdullahi","family":"Mahgoub","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"2025082701145435000_14.5.e240020.1","unstructured":"Sitammagari KK , Masood W . 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Available: https:\/\/www.ninds.nih.gov\/Disorders\/Patient-Caregiver-Education\/Fact-Sheets\/Creutzfeldt-Jakob-Disease-Fact-Sheet [Accessed Jun 2020]."},{"key":"2025082701145435000_14.5.e240020.3","first-page":"1","article-title":"An evaluation of rapidly progressive dementia culminating in a diagnosis of Creutzfeldt\u2013Jakob disease","volume":"2018","author":"Parmar","year":"2018","journal-title":"Case Rep Infect Dis"},{"key":"2025082701145435000_14.5.e240020.4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/2735329","article-title":"A case of sporadic Creutzfeldt-Jakob disease presenting as conversion disorder","volume":"2017","author":"Yegya-Raman","year":"2017","journal-title":"Case Rep Psychiatry"},{"key":"2025082701145435000_14.5.e240020.5","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.65"},{"key":"2025082701145435000_14.5.e240020.6","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.12.1751"},{"key":"2025082701145435000_14.5.e240020.7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-153"},{"key":"2025082701145435000_14.5.e240020.8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23589"},{"key":"2025082701145435000_14.5.e240020.9","unstructured":"National prion disease pathology surveillance center, 2021. Available: https:\/\/case.edu\/medicine\/pathology\/divisions\/prion-center\/ [Accessed 18 Mar 2021]."},{"key":"2025082701145435000_14.5.e240020.10","unstructured":"CDC\u2019s Diagnostic Criteria for Creutzfeldt-Jakob Disease (CJD), 2018. Available: https:\/\/www.cdc.gov\/prions\/cjd\/diagnostic-criteria.html [Accessed 15 Mar 2021]."},{"key":"2025082701145435000_14.5.e240020.11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pop.2019.05.007","article-title":"Geriatric palliative care","volume":"46","author":"Lazris","year":"2019","journal-title":"Prim Care"},{"key":"2025082701145435000_14.5.e240020.12","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315942"},{"key":"2025082701145435000_14.5.e240020.13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00041327-200106000-00008","article-title":"The Heidenhain variant of Creutzfeldt-Jakob disease: clinical, pathologic, and neuroimaging findings","volume":"21","author":"Jacobs","year":"2001","journal-title":"J Neuroophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:15:09Z","timestamp":1756282509000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,11]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2020-240020"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240020","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}