{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:40Z","timestamp":1756339360646,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>We report a 61-year-old woman with primary right breast cancer and metastatic lymphadenopathy in the contralateral axilla. This case represents a clinical dilemma because primary breast cancer, occult contralateral breast cancer and extra-mammary primary lesion can all be the source of the contralateral axillary metastasis. The patient underwent bilateral modified radical mastectomy. Immunohistochemistry revealed that the right breast was positive for estrogen receptor (ER) and progesterone receptor (PR), but negative for human epidermal growth factor receptor-2 (HER2). In contrast, the right and left axillary lymph nodes were positive for ER, but negative for PR and HER2. There was no evidence of occult primary cancers or extra-mammary tumours.<\/jats:p>","DOI":"10.1136\/bcr-2020-240036","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T18:30:23Z","timestamp":1612895423000},"page":"e240036","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Contralateral axillary metastasis: a diagnostic and therapeutic clinical dilemma"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9382-5180","authenticated-orcid":false,"given":"Hussain Adnan","family":"Abdulla","sequence":"first","affiliation":[{"name":"Department of Surgery, Salmaniya Medical Complex, Manama, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-1951","authenticated-orcid":false,"given":"Asma","family":"AlQaseer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Salmaniya Medical Complex, Manama, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zain","family":"Bukamal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Salmaniya Medical Complex, Manama, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Alrayes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Salmaniya Medical Complex, Manama, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"2025082700184637000_14.2.e240036.1","first-page":"713","article-title":"[Contralateral axillary lymph node metastasis of cancer of the breast]","volume":"85","author":"Daoud","year":"1998","journal-title":"Bull Cancer"},{"key":"2025082700184637000_14.2.e240036.2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.clbc.2017.10.019","article-title":"Isolated contralateral axillary lymph node involvement in breast cancer represents a locally advanced disease not distant metastases","volume":"18","author":"Chkheidze","year":"2018","journal-title":"Clin Breast Cancer"},{"key":"2025082700184637000_14.2.e240036.3","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/1778.19258","article-title":"Management of contralateral axillary lymph node metastasis from breast cancer: a clinical dilemma","volume":"100","author":"Wang","year":"2014","journal-title":"Tumori"},{"key":"2025082700184637000_14.2.e240036.4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1524-4741.2007.00390.x","article-title":"The presentation of contralateral axillary lymph node metastases from breast carcinoma: a clinical management dilemma","volume":"13","author":"Huston","year":"2007","journal-title":"Breast J"},{"key":"2025082700184637000_14.2.e240036.5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.breast.2014.03.004","article-title":"Contralateral axillary nodal involvement from invasive breast cancer","volume":"23","author":"Kiluk","year":"2014","journal-title":"Breast"},{"key":"2025082700184637000_14.2.e240036.6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ejso.2011.01.024","article-title":"Characteristics of and therapeutic options for contralateral axillary lymph node metastasis in breast cancer","volume":"37","author":"Morcos","year":"2011","journal-title":"Eur J Surg Oncol"},{"key":"2025082700184637000_14.2.e240036.7","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1159\/000440662","article-title":"Is it contralateral axillary metastasis or occult breast cancer?: a confusing case report","volume":"8","author":"Son","year":"2015","journal-title":"Case Rep Oncol"},{"key":"2025082700184637000_14.2.e240036.8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1067\/S0039-6060(03)00247-2","article-title":"Breast cancer draining to bilateral axillary sentinel lymph nodes","volume":"134","author":"Allweis","year":"2003","journal-title":"Surgery"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:18:55Z","timestamp":1756279135000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,9]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-240036"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240036","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}