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Given the advanced metastatic nature of her disease, imatinib was offered with a palliative intent. While waiting for treatment she developed a spinal cord compression, managed with radiotherapy. She commenced imatinib and her disease remained stable for 9 months before progressing clinically and radiologically. This case demonstrates an unusual pattern of metastatic chordoma and provides further rationale for imatinib in such patients.<\/jats:p>","DOI":"10.1136\/bcr-2020-240062","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T10:45:21Z","timestamp":1642589121000},"page":"e240062","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Metastatic chordoma with pancreatic disease and response to imatinib"],"prefix":"10.1136","volume":"15","author":[{"given":"Eleanor V","family":"Klejnow","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Hoban","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Queen Elizabeth University Hospital Campus, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Nixon","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-4100","authenticated-orcid":false,"given":"Thomas Robert","family":"Elswood","sequence":"additional","affiliation":[{"name":"Department of Radiology, NHS Greater Glasgow and Clyde, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"2025082800030136000_15.1.e240062.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70337-0"},{"key":"2025082800030136000_15.1.e240062.2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/72.5.765"},{"key":"2025082800030136000_15.1.e240062.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931115)72:10<2943::AID-CNCR2820721014>3.0.CO;2-6"},{"key":"2025082800030136000_15.1.e240062.4","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-11-1344"},{"key":"2025082800030136000_15.1.e240062.5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20618"},{"key":"2025082800030136000_15.1.e240062.6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.3656"},{"key":"2025082800030136000_15.1.e240062.7","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1947.02300280041002"},{"key":"2025082800030136000_15.1.e240062.8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195211)5:6<1170::AID-CNCR2820050613>3.0.CO;2-C"},{"key":"2025082800030136000_15.1.e240062.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra013339"},{"key":"2025082800030136000_15.1.e240062.10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2265"},{"key":"2025082800030136000_15.1.e240062.11","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.ejca.2015.07.038","article-title":"Imatinib in advanced chordoma: a retrospective case series analysis","volume":"51","author":"Hindi","year":"2015","journal-title":"Eur J Cancer"},{"key":"2025082800030136000_15.1.e240062.12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv300"},{"key":"2025082800030136000_15.1.e240062.13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.4452"},{"key":"2025082800030136000_15.1.e240062.14","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx054"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:03:10Z","timestamp":1756364590000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,19]]},"published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1136\/bcr-2020-240062"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240062","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}