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However, he displayed atypical clinical features of same, antinuclear antibody was negative and symptoms were refractory to various immunosuppressive therapies. CT imaging revealed a gastric mass, which later proved to be a gastrointestinal stromal tumour (GIST). Resection of the GIST leads to minimal symptomatic improvement. Surveillance imaging 1\u2009year later revealed metastatic deposits. He was subsequently initiated on imatinib therapy, which led to a rapid improvement in fibrotic changes within weeks. While there have been previous descriptions of paraneoplastic fibrotic disorders, this is the first description of a scleroderma mimic in the setting of a GIST. It highlights an important potential overlap in the pathogenesis of these disease processes and the potential efficacy of tyrosine kinase inhibitors for scleroderma-like fibrotic disorders.<\/jats:p>","DOI":"10.1136\/bcr-2020-240211","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T13:30:59Z","timestamp":1614951059000},"page":"e240211","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Novel case of a scleroderma-mimicking syndrome associated with gastrointestinal stromal tumour"],"prefix":"10.1136","volume":"14","author":[{"given":"Zaran Ahmad","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Beaumont Hospital, Dublin, Leinster, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Lin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Beaumont Hospital, Dublin, Leinster, 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