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GI amyloidosis can present with a wide range of symptoms including diarrhoea, bleeding and obstruction. This case illustrates a patient with localised jejunal amyloid light chain disease that was diagnosed serendipitously during a workup for haematuria. Our patient was otherwise asymptomatic, but this case underscores the importance of considering amyloidosis as a possible cause of isolated masses of the small intestine.<\/jats:p>","DOI":"10.1136\/bcr-2020-240226","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:31:17Z","timestamp":1621945877000},"page":"e240226","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Unusual case of amyloidosis presenting as a jejunal mass"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6798-4767","authenticated-orcid":false,"given":"Sachin","family":"Mohan","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology, Regions Hospital, Saint Paul, Minnesota, USA"},{"name":"Department of Gastroenterology and Hepatology, University of Minnesota System, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Graziano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Rochester, Rochester, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Campbell","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University of Minnesota System, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irshad H","family":"Jafri","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Regions Hospital, Saint Paul, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"2025082709252124000_14.5.e240226.1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJMra023144","article-title":"Molecular mechanisms of amyloidosis","volume":"349","author":"Merlini","year":"2003","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025082709252124000_14.5.e240226.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03682.x"},{"key":"2025082709252124000_14.5.e240226.3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0025-6196(12)60634-X","article-title":"Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis","volume":"68","author":"Menke","year":"1993","journal-title":"Mayo Clin Proc"},{"key":"2025082709252124000_14.5.e240226.4","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.068155"},{"key":"2025082709252124000_14.5.e240226.5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/MEG.0000000000000695","article-title":"Amyloidosis of the gastrointestinal tract and the liver: clinical context, diagnosis and management","volume":"28","author":"Syed","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025082709252124000_14.5.e240226.6","doi-asserted-by":"crossref","DOI":"10.1007\/s11894-018-0616-y","article-title":"Small bowel amyloidosis","volume":"20","author":"Bansal","year":"2018","journal-title":"Curr Gastroenterol Rep"},{"key":"2025082709252124000_14.5.e240226.7","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.1"},{"key":"2025082709252124000_14.5.e240226.8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5217\/ir.2014.12.3.245","article-title":"A case of localized amyloid light-chain amyloidosis in the small intestine","volume":"12","author":"Choi","year":"2014","journal-title":"Intest Res"},{"key":"2025082709252124000_14.5.e240226.9","first-page":"469","article-title":"Clinical and endoscopic manifestations of gastrointestinal amyloidosis: a case series","volume":"91","author":"Koop","year":"2018","journal-title":"Clujul Med"},{"key":"2025082709252124000_14.5.e240226.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(94)70008-7"},{"key":"2025082709252124000_14.5.e240226.11","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-2-9100"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:25:28Z","timestamp":1756311928000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,25]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2020-240226"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240226","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}