{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:16:41Z","timestamp":1784776601476,"version":"3.55.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,2,10]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>A previously fit and well 76-year-old man, presented with distal lower limb sensory symptoms suggestive of peripheral sensory neuropathy, associated with positive anti-MAG antibodies (myelin associated glycoprotein) and IgM paraprotein. Bone marrow biopsy showed lymphoplasmocytoid lymphoma (Waldenstrom\u2019s macroglobulinaemia, WM), consequently positive for MYD88 mutation. He subsequently developed medullary carcinoma of the thyroid, most likely secondary to WM. He underwent a successful total thyroidectomy and four treatment doses of rituximab, which proved beneficial. He is currently stable and under multidisciplinary monitoring. His sensory symptoms have improved following rituximab treatment and his WM is under control.<\/jats:p>","DOI":"10.1136\/bcr-2020-240242","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T10:59:20Z","timestamp":1614077960000},"page":"e240242","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["IgM paraprotein and anti-MAG sensory polyneuropathy associated with Waldenstrom\u2019s macroglobulinaemia and medullary carcinoma of the thyroid"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-9801","authenticated-orcid":false,"given":"Yunfei","family":"Yang","sequence":"first","affiliation":[{"name":"Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Canepa","sequence":"additional","affiliation":[{"name":"Department of Neurology, James Paget University Hospital NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"2025082802571970000_14.2.e240242.1","first-page":"742","article-title":"Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies","volume":"10","author":"Lunn","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2025082802571970000_14.2.e240242.2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21577"},{"key":"2025082802571970000_14.2.e240242.3","first-page":"14","article-title":"Peripheral neuropathies associated with monoclonal gammopathies of undetermined significance","volume":"5","author":"Kelly","year":"2008","journal-title":"Rev Neurol Dis"},{"key":"2025082802571970000_14.2.e240242.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319857"},{"key":"2025082802571970000_14.2.e240242.5","first-page":"301","article-title":"Peripheral neuropathy and anti-MAG antibodies","volume":"3","author":"Latov","year":"1988","journal-title":"Crit Rev Neurobiol"},{"key":"2025082802571970000_14.2.e240242.6","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0237-4"},{"key":"2025082802571970000_14.2.e240242.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.01.012"},{"key":"2025082802571970000_14.2.e240242.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb12563.x"},{"key":"2025082802571970000_14.2.e240242.9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/450391","article-title":"Heterogeneity of polyneuropathy associated with anti-MAG antibodies","volume":"2015","author":"Magy","year":"2015","journal-title":"J Immunol Res"},{"key":"2025082802571970000_14.2.e240242.10","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-228376","article-title":"Waldenstrom-associated anti-MAG paraprotein polyneuropathy with neurogenic tremor","volume":"12","author":"Canepa","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025082802571970000_14.2.e240242.11","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100011483"},{"key":"2025082802571970000_14.2.e240242.12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr119"},{"key":"2025082802571970000_14.2.e240242.13","doi-asserted-by":"crossref","unstructured":"Castillo J , Olszewski A , Hunter Z . 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