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Her coagulopathy and visual deficits improved following vitamin K and A supplementation, respectively. She delivered at 32 2\/7 weeks following preterm labour. This case highlights several unique aspects in the care of pregnant women with liver disease. These patients are at risk for fat-soluble vitamin deficiencies which can result in significant coagulopathy and rarely, visual deficits due to vitamin A deficiency. Prompt treatment is necessary to prevent permanent sequelae.<\/jats:p>","DOI":"10.1136\/bcr-2020-240248","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T11:56:34Z","timestamp":1615377394000},"page":"e240248","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Severe vitamin deficiencies in pregnancy complicated by progressive familial intrahepatic cholestasis"],"prefix":"10.1136","volume":"14","author":[{"given":"Amanda Caroline","family":"Mahle","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard David","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-8771","authenticated-orcid":false,"given":"Zane","family":"Frazer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5143-6937","authenticated-orcid":false,"given":"Christopher","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"2025082804130076000_14.3.e240248.1","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.3748\/wjg.v26.i47.7470","article-title":"Molecular overview of progressive familial intrahepatic cholestasis","volume":"26","author":"Amirneni","year":"2020","journal-title":"World J Gastroenterol"},{"key":"2025082804130076000_14.3.e240248.2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010273","article-title":"Gene therapy for progressive familial intrahepatic cholestasis: current progress and future prospects","volume":"22","author":"Bosma","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025082804130076000_14.3.e240248.3","unstructured":"Gestational Hypertension and Preeclampsia . 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