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However, a flexible sigmoidoscopy revealed an ulceroproliferative lesion in the rectum, which was identified as an amelanotic anorectal malignant melanoma on immunohistochemistry. No local or distant metastases were noted on radiological imaging. The tumour enlarged progressively and was managed with laparotomy and defunctioning stoma followed by palliative chemotherapy and immunotherapy. This is the first such case reported in literature, highlighting the importance of endoscopic assessment and the need to consider other differential diagnosis in patients with symptoms of IBD flare.<\/jats:p>","DOI":"10.1136\/bcr-2020-240398","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T13:02:49Z","timestamp":1615899769000},"page":"e240398","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Amelanotic anorectal malignant melanoma in an ulcerative colitis patient: a rare coincidence or a rare association"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5161-1747","authenticated-orcid":false,"given":"Anish John","family":"Kuriakose Kuzhiyanjal","sequence":"first","affiliation":[{"name":"Gastroenterology, The Royal Oldham Hospital, The Pennine Acute Hospitals NHS Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4699-2263","authenticated-orcid":false,"given":"Gaurav Bhaskar","family":"Nigam","sequence":"additional","affiliation":[{"name":"Gastroenterology, The Royal Oldham Hospital, The Pennine Acute Hospitals NHS Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Afzal","sequence":"additional","affiliation":[{"name":"Gastroenterology, The Royal Oldham Hospital, The Pennine Acute Hospitals NHS Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"2025082722395584000_14.3.e240398.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000447259","article-title":"Malignancies in patients with inflammatory bowel disease: a single-centre experience","volume":"94","author":"Madanchi","year":"2016","journal-title":"Digestion"},{"key":"2025082722395584000_14.3.e240398.2","unstructured":"Matthews NH , Li W-Q QAA , Weinstock MA , et al . 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