{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:31:37Z","timestamp":1767065497763,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,1,19]]},"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Perianal Paget disease (PPD) is a rare neoplastic condition defined by the presence of atypical Paget cells in the perianal skin, the aetiology of which remains largely unknown. It can be divided in primary forms, arising as an intraepithelial disease or manifestation of an underlying skin adenocarcinoma or secondary forms resulting from epidermotropic spread or metastasis of a concealed carcinoma. Indeed, because of its rarity, clear options regarding the treatment of these patients are yet to be clarified. A high level of suspicion is needed whenever dealing with any unhealed perianal skin lesions and, therefore, the need for close long-term follow-up must be highlighted. Herein, two cases of PPD, one primary and another secondary, treated at the same institution, are presented in an attempt to document the involved complexity and to bring further insight into the understanding of this entity.<\/jats:p>","DOI":"10.1136\/bcr-2020-240435","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T01:48:45Z","timestamp":1612489725000},"page":"e240435","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Perianal Paget\u2019s disease: one century later and still a challenge"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-1468","authenticated-orcid":false,"given":"Gon\u00e7alo Jo\u00e3o","family":"Guidi","sequence":"first","affiliation":[{"name":"General Surgery, Centro Hospitalar de Tr\u00e1s-os-Montes e Alto Douro EPE, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Pinto de Sousa","sequence":"additional","affiliation":[{"name":"Surgery, Tras-os-montes and Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Marques","sequence":"additional","affiliation":[{"name":"Surgery, Tras-os-montes and Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1tia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Surgery, Tras-os-montes and Alto Douro Hospital Centre, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"2025082802453791000_14.2.e240435.1","first-page":"77","article-title":"Vulvo-Perineal and perianal Paget disease. radical excision and reconstruction with Singapore flap","volume":"62","author":"Panoskaltsis","year":"2019","journal-title":"Acta Medica"},{"key":"2025082802453791000_14.2.e240435.2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000256382","article-title":"Extramammary perianal Paget's disease","volume":"3","author":"Al Hallak","year":"2009","journal-title":"Case Rep Gastroenterol"},{"key":"2025082802453791000_14.2.e240435.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(09)70425-3"},{"key":"2025082802453791000_14.2.e240435.4","doi-asserted-by":"crossref","DOI":"10.1186\/s13000-020-00952-w","article-title":"Perianal Paget's disease: a clinicopathological and immunohistochemical study of 13 cases","volume":"15","author":"Liao","year":"2020","journal-title":"Diagn Pathol"},{"key":"2025082802453791000_14.2.e240435.5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.amjsurg.2013.04.005","article-title":"Staged marginal contoured and central excision technique in the surgical management of perianal Paget's disease","volume":"207","author":"M\u00f6ller","year":"2014","journal-title":"Am J Surg"},{"key":"2025082802453791000_14.2.e240435.6","doi-asserted-by":"crossref","first-page":"e496","DOI":"10.3747\/co.19.1144","article-title":"Perianal Paget disease treated definitively with radiotherapy","volume":"19","author":"Mann","year":"2012","journal-title":"Curr Oncol"},{"key":"2025082802453791000_14.2.e240435.7","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011638","article-title":"Perianal Paget disease treated with wide excision and thigh skin flap reconstruction: a case report and review of literature","volume":"97","author":"Shen","year":"2018","journal-title":"Medicine"},{"key":"2025082802453791000_14.2.e240435.8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4321\/S1130-01082014000100017","article-title":"Paget disease presenting as a perianal papilla: report of a unique case","volume":"106","author":"Ribeiro","year":"2014","journal-title":"Rev Esp Enferm Dig"},{"key":"2025082802453791000_14.2.e240435.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02052147"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:45:44Z","timestamp":1756374344000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,4]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1136\/bcr-2020-240435"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240435","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}