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A CT scan of the chest showed a large anterior mediastinal mass unrelated to the lung, suggesting that the anterior mediastinum was the primary origin of the tumour. The patient was planned to receive platinum\/etoposide chemotherapy for a metastatic mediastinal large cell neuroendocrine carcinoma. Unfortunately, her health deteriorated, and she was unfit to undergo any further treatment. She was treated palliatively and died 2\u2009months after the diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2020-240453","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:31:22Z","timestamp":1621945882000},"page":"e240453","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Large cell neuroendocrine carcinoma arising from the anterior mediastinum"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-4233","authenticated-orcid":false,"given":"Annalisa","family":"Montebello","sequence":"first","affiliation":[{"name":"Diabetes and Endocrinology, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizier","family":"Zahra Bianco","sequence":"additional","affiliation":[{"name":"Gastroenterology, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Babic","sequence":"additional","affiliation":[{"name":"Histopathology, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas Paul","family":"Delicata","sequence":"additional","affiliation":[{"name":"Gastroenterology, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville","family":"Azzopardi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Mater Dei Hospital, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"2025082702405578000_14.5.e240453.1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2169\/internalmedicine.0437-17","article-title":"Large cell neuroendocrine carcinoma of the mediastinum successfully treated with systemic chemotherapy after palliative radiotherapy","volume":"58","author":"Hidaka","year":"2019","journal-title":"Intern Med"},{"key":"2025082702405578000_14.5.e240453.2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s11748-012-0157-5","article-title":"Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum","volume":"61","author":"Maeda","year":"2013","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"2025082702405578000_14.5.e240453.3","unstructured":"UpToDate . 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