{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:46:19Z","timestamp":1784119579211,"version":"3.55.0"},"reference-count":9,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,26]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Tractional retinal detachment is an uncommon complication of intravitreal anti-vascular endothelial growth factor (VEGF) injection wherein the drug triggers tractional retinal detachment as a result of fibrovascular membrane contraction. We present a case of a 42-year-old hypertensive woman diagnosed with chronic central retinal vein occlusion on both eyes. The right eye had total retinal detachment and neovascular glaucoma, while the left eye had retinal neovascularisation. Panretinal photocoagulation and intravitreal anti-VEGF injection was started on the left eye. However, she was lost to follow-up. She returned 4 months later with extensive tractional retinal detachment involving the macula on the left eye. She subsequently underwent vitrectomy with endolaser and silicone oil tamponade on the left eye. The anti-VEGF \u2018crunch\u2019 results from regression of fibrovascular proliferation with a concurrent increase in fibrosis, resulting in worsening retinal traction. With the widespread use of anti-VEGF agents, ophthalmologists need to be aware of this vision-threatening complication.<\/jats:p>","DOI":"10.1136\/bcr-2020-240506","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T13:29:35Z","timestamp":1619616575000},"page":"e240506","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Tractional retinal detachment (\u2018crunch\u2019 phenomenon) from intravitreal anti-vascular endothelial growth factor injection in central retinal vein occlusion"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7983-6369","authenticated-orcid":false,"given":"Albert John","family":"Bromeo","sequence":"first","affiliation":[{"name":"Asian Eye Institute, Makati City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadeo","family":"Veloso","sequence":"additional","affiliation":[{"name":"Asian Eye Institute, Makati City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweet Jorlene","family":"Lerit","sequence":"additional","affiliation":[{"name":"Asian Eye Institute, Makati City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron Carlo","family":"Gomez","sequence":"additional","affiliation":[{"name":"Asian Eye Institute, Makati City, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"2025082700294092000_14.4.e240506.1","unstructured":"Flynn H , Chen R . Avoiding and managing complications of vitreoretinal procedures. retina today, 2014. Available: https:\/\/retinatoday.com\/pdfs\/0514RT_VBS_Flynn.pdf"},{"key":"2025082700294092000_14.4.e240506.2","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.3928\/23258160-20180907-16","article-title":"Fellow Eye Anti-VEGF \u2018Crunch\u2019 Effect in Retinopathy of Prematurity","volume":"49","author":"Wood","year":"2018","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"2025082700294092000_14.4.e240506.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7573\/dic.212532","article-title":"The role of anti-vascular endothelial growth factor (anti-VEGF) in the management of proliferative diabetic retinopathy","volume":"7","author":"Zhao","year":"2018","journal-title":"DIC"},{"key":"2025082700294092000_14.4.e240506.4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.127142"},{"key":"2025082700294092000_14.4.e240506.5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000502970","article-title":"Vitreoretinal surgery and Panretinal photocoagulation in a patient with multiple large retinal capillary hemangiomas (von Hippel-Lindau disease): a novel approach","volume":"10","author":"Sturzeneker","year":"2019","journal-title":"Case Rep Ophthalmol"},{"key":"2025082700294092000_14.4.e240506.6","doi-asserted-by":"crossref","first-page":"100508","DOI":"10.1016\/j.ajoc.2019.100508","article-title":"Vitrectomy for a secondary epiretinal membrane following treatment of adult-onset Coats' disease","volume":"15","author":"Elnahry","year":"2019","journal-title":"Am J Ophthalmol Case Rep"},{"key":"2025082700294092000_14.4.e240506.7","first-page":"38","article-title":"Laser therapy vs anti-VEGF for diabetic retinopathy","volume":"16","author":"Lim","year":"2019","journal-title":"Retinal Physician"},{"key":"2025082700294092000_14.4.e240506.8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ajo.2017.01.010","article-title":"Intravitreal bevacizumab for the treatment of vitreous hemorrhage due to proliferative diabetic retinopathy","volume":"176","author":"Parikh","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"2025082700294092000_14.4.e240506.9","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-308199"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:29:47Z","timestamp":1756279787000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,28]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2020-240506"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240506","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}