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We present a unique case of a neurological manifestation of a patient with structural brain disease who was COVID-19 positive and developed mental status changes, new-onset seizures and findings suggestive of viral meningitis on lumbar puncture. We also review the literature and discuss our case in the context of the other cases reported. We highlight the value of considering seizures and encephalopathy as one of the presenting features of COVID-19 disease.<\/jats:p>","DOI":"10.1136\/bcr-2020-240576","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T12:49:04Z","timestamp":1616590144000},"page":"e240576","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["A young man presenting with encephalopathy and seizures secondary to SARS-CoV-2"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-7964","authenticated-orcid":false,"given":"Bilal Athar","family":"Jalil","sequence":"first","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Baylor Scott and White Medical Center, Waxahachie, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-3865","authenticated-orcid":false,"given":"Mohsin","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Baylor Scott and White Medical Center, Waxahachie, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Maqbul","family":"Khan","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Baylor Scott and White Medical Center, Waxahachie, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Glenn","family":"Ledbetter","sequence":"additional","affiliation":[{"name":"Internal Medicine, Baylor Scott and White Medical Center, Waxahachie, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"2025082701133724000_14.3.e240576.1","article-title":"A review of neurological complications of COVID-19","volume":"12","author":"Sheraton","year":"2020","journal-title":"Cureus"},{"key":"2025082701133724000_14.3.e240576.2","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol"},{"key":"2025082701133724000_14.3.e240576.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"2025082701133724000_14.3.e240576.4","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00386"},{"key":"2025082701133724000_14.3.e240576.5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12028-020-01006-1","article-title":"Acute symptomatic seizures in critically ill patients with COVID-19: is there an association?","volume":"34","author":"Hepburn","year":"2021","journal-title":"Neurocrit Care"},{"key":"2025082701133724000_14.3.e240576.6","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2020.e00782","article-title":"COVID-19 presenting with seizures","volume":"20","author":"Sohal","year":"2020","journal-title":"IDCases"},{"key":"2025082701133724000_14.3.e240576.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.062"},{"key":"2025082701133724000_14.3.e240576.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2008597"},{"key":"2025082701133724000_14.3.e240576.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.04.009"},{"key":"2025082701133724000_14.3.e240576.10","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-239015","article-title":"Non-convulsive status epilepticus: COVID-19 or clozapine induced?","volume":"13","author":"Sokolov","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2025082701133724000_14.3.e240576.11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.seizure.2020.05.005","article-title":"Seizures associated with coronavirus infections","volume":"79","author":"Asadi-Pooya","year":"2020","journal-title":"Seizure"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:13:43Z","timestamp":1756282423000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,24]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1136\/bcr-2020-240576"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240576","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}