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Metastatic RCC should be in the differential diagnosis of patients with facial masses, especially if associated with symptoms suggestive of a systemic involvement such as haematuria. Despite treatment, patients with metastatic RCC tend to have a dismal prognosis. However, early stage diagnosis of metastatic disease can considerably limit surgical complications and improve survival rate in these patients.<\/jats:p>","DOI":"10.1136\/bcr-2020-240588","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T14:35:53Z","timestamp":1618324553000},"page":"e240588","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Orbit and sinonasal metastasis as presenting sign of renal cell carcinoma"],"prefix":"10.1136","volume":"14","author":[{"given":"Zalathiel","family":"Barajas-Ochoa","sequence":"first","affiliation":[{"name":"Departamento de Urolog\u00eda, Hospital de Especialidades No. 25, Instituto Mexicano del Seguro Social Delegaci\u00f3n Nuevo Le\u00f3n, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4274-2761","authenticated-orcid":false,"given":"Giselle Alexandra","family":"Suero-Abreu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-0534","authenticated-orcid":false,"given":"Aldo","family":"Barajas-Ochoa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"2025082711160067000_14.4.e240588.1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/annonc\/mdz056","article-title":"Renal cell carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up\u2020","volume":"30","author":"Escudier","year":"2019","journal-title":"Ann Oncol"},{"key":"2025082711160067000_14.4.e240588.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.02.024"},{"key":"2025082711160067000_14.4.e240588.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4797"},{"key":"2025082711160067000_14.4.e240588.4","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1038\/nrdp.2017.9","article-title":"Renal cell carcinoma","volume":"3","author":"Hsieh","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"2025082711160067000_14.4.e240588.5","unstructured":"Atkins MB . 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