{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:10:05Z","timestamp":1756321805818,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,5,6]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Mixed gestational trophoblastic neoplasias (GTNs) are rare placental tumours that arise from abnormal fertilisation events. To date, only 34 patients with mixed GTNs have been reported in the literature. As such, the management of such cases remains challenging. This report presents a case of a mixed GTN that was further complicated by a synchronous primary lung adenocarcinoma. Our patient was initially treated with hysterectomy, with surveillance labwork showing persistence of her malignancy. She then began combination chemotherapy, at the end of which she appeared to be in remission clinically. Unfortunately, subsequent imaging showed the persistence of pulmonary nodules that were ultimately resected, demonstrating a new primary lung adenocarcinoma. At present, she remains free of both cancers 2\u2009years after her initial diagnosis. The complexity of this case underscores the importance of patient-centred treatment for rare tumours and the role of a multidisciplinary team in the effort to provide holistic care.<\/jats:p>","DOI":"10.1136\/bcr-2020-240606","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T14:37:10Z","timestamp":1622039830000},"page":"e240606","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnosis and management of a metastatic mixed gestational trophoblastic neoplasia with synchronous primary lung cancer"],"prefix":"10.1136","volume":"14","author":[{"given":"Varun","family":"Iyengar","sequence":"first","affiliation":[{"name":"Alpert Medical School of Brown University, Providence, Rhode Island, USA"},{"name":"Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hetal","family":"Mistry","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University, Providence, Rhode Island, USA"},{"name":"Rhode Island Hospital, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Hibbitt","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei","family":"Shimanovsky","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University, Providence, Rhode Island, USA"},{"name":"Rhode Island Hospital, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"2025082711495512000_14.5.e240606.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.073"},{"key":"2025082711495512000_14.5.e240606.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.072"},{"key":"2025082711495512000_14.5.e240606.3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ijgo.12615","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"143","author":"Ngan","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"2025082711495512000_14.5.e240606.4","doi-asserted-by":"crossref","DOI":"10.1186\/1752-1947-4-379","article-title":"Choriocarcinoma in a 73-year-old woman: a case report and review of the literature","volume":"4","author":"Desai","year":"2010","journal-title":"J Med Case Rep"},{"key":"2025082711495512000_14.5.e240606.5","unstructured":"PDQ Adult Treatment Editorial Board . 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