{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:13:29Z","timestamp":1757452409563,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,2]]},"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Nasal chondromesenchymal hamartoma (NCMH) is an extremely rare benign tumour of the nasal cavity predominantly described in infants. We report a case involving a 48-year-old woman who had been diagnosed with NCMH a year earlier and now re-presented with a short history of progressive nasal blockage, recurrent epistaxis and orbital apex syndrome. Histopathology was suggestive of malignant transformation into sinonasal sarcoma. However, following multidisciplinary team (MDT) discussions, including second and third opinions from external departments, the histological diagnosis was revised to \u2018NCMH with bizarre stromal cells\u2019. Despite this, the lesion demonstrated malignant features of rapid, invasive growth and was treated with palliative radiotherapy. The patient later developed radiological evidence of lung and liver metastases with subsequent pulmonary emboli. Shortly after this, she passed away. This case is unique in its diagnostic challenge, with ambiguous histopathological findings, and highlights the importance of an MDT approach when managing complex sinonasal tumours.<\/jats:p>","DOI":"10.1136\/bcr-2020-240643","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T12:16:14Z","timestamp":1627474574000},"page":"e240643","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Adult nasal chondromesenchymal hamartoma: a rare and benign tumour with aggressive malignant transformation"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-0767","authenticated-orcid":false,"given":"Rachael","family":"Collins","sequence":"first","affiliation":[{"name":"Norwich Medical School, University of East Anglia Norwich Medical School, Norwich, UK"},{"name":"ENT\/Otolaryngology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Lafford","sequence":"additional","affiliation":[{"name":"Plastic Surgery, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheneen","family":"Meghji","sequence":"additional","affiliation":[{"name":"ENT\/Otolaryngology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Burrows","sequence":"additional","affiliation":[{"name":"ENT\/Otolaryngology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"2025082706583446000_14.7.e240643.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-014-1474-9"},{"key":"2025082706583446000_14.7.e240643.2","first-page":"337","article-title":"Malignant transformation of nasal chondromesenchymal hamartoma in adult: a case report and review of the literature","volume":"28","author":"Li","year":"2013","journal-title":"Histol Histopathol"},{"key":"2025082706583446000_14.7.e240643.3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199804000-00006"},{"key":"2025082706583446000_14.7.e240643.4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40463-015-0077-3","article-title":"Nasal Chondromesenchymal hamartoma (NCMH): a systematic review of the literature with a new case report","volume":"44","author":"Mason","year":"2015","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"2025082706583446000_14.7.e240643.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5971786","article-title":"Nasal Chondromesenchymal hamartoma: rare case report in an elderly patient and brief review of literature","volume":"2018","author":"Mirchia","year":"2018","journal-title":"Case Rep Pathol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:58:48Z","timestamp":1756303128000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":5,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,28]]},"published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1136\/bcr-2020-240643"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240643","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}