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The patient was treated with naloxone and his symptoms improved. Retrospectively, it was suspected that an interaction between clarithromycin and methadone might have contributed to the toxidrome. Respiratory failure has not been previously prescribed for this combination of medication and is of high importance for physicians and pharmacists around the world.<\/jats:p>","DOI":"10.1136\/bcr-2020-240647","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:31:55Z","timestamp":1621945915000},"page":"e240647","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Interaction between methadone and clarithromycin as the suspected cause of an opioid toxidrome"],"prefix":"10.1136","volume":"14","author":[{"given":"Blair","family":"Wallace","sequence":"first","affiliation":[{"name":"Intensive Care, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Edwardes","sequence":"additional","affiliation":[{"name":"Pharmacy, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Subbe","sequence":"additional","affiliation":[{"name":"Acute Internal Medicine, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Murtaza","sequence":"additional","affiliation":[{"name":"Endocrinology, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"2025082707450744000_14.5.e240647.1","unstructured":"Joint Formularly Committee . 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