{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:41:05Z","timestamp":1766983265061,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,17]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Small-cell lung cancer (SCLC) is a very fast growing form of cancer and is characterised by early metastasis. As a result, chemotherapy is the mainstay of treatment. Platinum-containing combination regimens are the current treatment of choice for limited stage-SCLC and extensive stage SCLC. Various adverse effects after cisplatin and etoposide chemotherapy include nausea, nephrotoxicity, cardiotoxicity, hepatotoxicity, neurotoxicity, alopecia, gastrointestinal toxicity and myelosuppression. However, severe headache has not been reported yet. Here, we report one such case of severe refractory headache postcisplatin and etoposide chemotherapy which responded only to change in chemotherapy regime. All pertinent causes of headache were ruled out prior to changing the chemotherapy regimen.<\/jats:p>","DOI":"10.1136\/bcr-2020-240654","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T13:33:50Z","timestamp":1619616830000},"page":"e240654","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Chemotherapy as cause of refractory severe headache in a case of small-cell lung cancer"],"prefix":"10.1136","volume":"14","author":[{"given":"Ankita Chouksey","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Sleep and Critical Care, All India Institute of Medical Science - Bhopal, Bhopal, Madhya pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-351X","authenticated-orcid":false,"given":"Abhishek","family":"Goyal","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, All India Institute of Medical Science - Bhopal, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkesh Kumar","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Sleep and Critical Care, All India Institute of Medical Science - Bhopal, Bhopal, Madhya pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anoohya","family":"Vangala","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, All India Institute of Medical Science - Bhopal, Bhopal, Madhya Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"2025082711192436000_14.4.e240654.1","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1200\/JCO.1985.3.11.1471","article-title":"VP-16 and cisplatin as first-line therapy for small-cell lung cancer","volume":"3","author":"Evans","year":"1985","journal-title":"J Clin Oncol"},{"key":"2025082711192436000_14.4.e240654.2","doi-asserted-by":"crossref","first-page":"07","DOI":"10.13005\/bpj\/1608","article-title":"Review on pharmacology of cisplatin: clinical use, toxicity and mechanism of resistance of cisplatin","volume":"12","author":"Aldossary","year":"2019","journal-title":"Biomed. 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