{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:39:21Z","timestamp":1782830361533,"version":"3.54.5"},"reference-count":9,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,20]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Gianotti-Crosti syndrome (GCS) is a self-limited condition, mainly affecting children younger than 6 years, less common in adolescents and adults. It consists of a viral exanthema with papular lesions with a flat top and symmetrical distribution, affecting predominantly extremities, gluteal region and extensor surfaces. It is often associated with viral infections but can also be related to bacterial infections, vaccination or be idiopathic. In this report, we present a case of GCS in a 13-year-old healthy female adolescent who presented with fever, odynophagia, prostration and diffuse maculopapular rash. The diagnosis of infectious mononucleosis due to infection by the Epstein-Barr virus was established. On the second week of the disease, a clinical recrudescence occurred, with worsening of the fever and modification of the exanthema characteristics. GCS is often an underdiagnosed entity. The differential diagnosis of viral exanthema can prove to be challenging and clinical suspicion is essential to achieve the diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2020-240747","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T13:22:49Z","timestamp":1617283369000},"page":"e240747","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Gianotti-Crosti syndrome: a challenging exanthema"],"prefix":"10.1136","volume":"14","author":[{"given":"Ana\u00edsa","family":"Afonso","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Centro Hospitalar de Set\u00fabal EPE, Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-9658","authenticated-orcid":false,"given":"Joana","family":"Cach\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centro Hospitalar de Set\u00fabal EPE, Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Laerte","family":"Pinto Junior","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Centro Hospitalar de Setubal EPE, Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centro Hospitalar de Set\u00fabal EPE, Set\u00fabal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"2025082707341960000_14.4.e240747.1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1590\/abd1806-4841.20164410","article-title":"Gianotti-Crosti syndrome: a case report of a teenager","volume":"91","author":"Pedreira","year":"2016","journal-title":"An Bras Dermatol"},{"key":"2025082707341960000_14.4.e240747.2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1590\/abd1806-4841.20186726","article-title":"Atypical Gianotti-Crosti syndrome","volume":"93","author":"Marcassi","year":"2018","journal-title":"An Bras Dermatol"},{"key":"2025082707341960000_14.4.e240747.3","first-page":"1","article-title":"Unusual presentation of Gianotti-Crosti syndrome due to Epstein-Barr virus infection","volume":"2016","author":"Al Dhaheri","year":"2016","journal-title":"Case Rep Dermatol Med"},{"key":"2025082707341960000_14.4.e240747.4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/00015550310007210","article-title":"Gianotti-Crosti syndrome and allergic background","volume":"83","author":"Ricci","year":"2003","journal-title":"Acta Derm Venereol"},{"key":"2025082707341960000_14.4.e240747.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.09.033"},{"key":"2025082707341960000_14.4.e240747.6","unstructured":"Chuh AAT . Md, FRCP f. Gianotti-Crosti syndrome (papular acrodermatitis). Uptodate, 2019."},{"key":"2025082707341960000_14.4.e240747.7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/pde.12886","article-title":"Is Gianotti-Crosti syndrome associated with atopy? A case-control study and a postulation on the intrinsic host factors in Gianotti-Crosti syndrome","volume":"33","author":"Chuh","year":"2016","journal-title":"Pediatr Dermatol"},{"key":"2025082707341960000_14.4.e240747.8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.clindermatol.2020.06.005","article-title":"Paraviral eruptions in the era of COVID-19: do some skin manifestations point to a natural resistance to SARS-CoV-2?","volume":"38","author":"Lipsker","year":"2020","journal-title":"Clin Dermatol"},{"key":"2025082707341960000_14.4.e240747.9","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.109289"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:34:29Z","timestamp":1756305269000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,1]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2020-240747"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240747","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}