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Although there are reports of COVID-19 infection in XLA, for the first time we report a case of possible reinfection. Lessons learnt from this case include the potential for reinfection of COVID-19 in a patient with a weakened immune system and the importance of repeating COVID-19 swabs in inpatients. Extra caution needs to be taken when providing care in groups of patients who have a weakened or absent immune system.<\/jats:p>","DOI":"10.1136\/bcr-2020-240765","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T13:34:31Z","timestamp":1614951271000},"page":"e240765","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Possible COVID-19 reinfection in a patient with X-linked agammaglobulinaemia"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-7507","authenticated-orcid":false,"given":"Sook Yin","family":"Loh","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Countess of Chester Hospital NHS Foundation Trust, Chester, Cheshire West and Chester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bassett","sequence":"additional","affiliation":[{"name":"Metabolic Medicine, Royal Liverpool University Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-5488","authenticated-orcid":false,"given":"Emily Jayne","family":"Hoodless","sequence":"additional","affiliation":[{"name":"Respiratory, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK"},{"name":"Respiratory Department, St. Helens, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Walshaw","sequence":"additional","affiliation":[{"name":"Respiratory Medicine, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"2025082711393124000_14.3.e240765.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"2025082711393124000_14.3.e240765.2","doi-asserted-by":"crossref","DOI":"10.3390\/v12060582","article-title":"Challenges in laboratory diagnosis of the novel coronavirus SARS-CoV-2","volume":"12","author":"Younes","year":"2020","journal-title":"Viruses"},{"key":"2025082711393124000_14.3.e240765.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001468"},{"key":"2025082711393124000_14.3.e240765.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2565"},{"key":"2025082711393124000_14.3.e240765.5","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/cid\/ciaa207","article-title":"Computed tomographic imaging of 3 patients with coronavirus disease 2019 pneumonia with negative virus real-time reverse-transcription polymerase chain reaction test","volume":"71","author":"Xu","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2025082711393124000_14.3.e240765.6","doi-asserted-by":"crossref","unstructured":"World Health Organization . 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