{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:44:44Z","timestamp":1758635084957,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,18]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Malignant lesions of the vermiform appendix make up a rare subset of colorectal cancer. While colorectal cancer frequently metastasises to the liver, lung, regional lymph nodes and peritoneum, metastasis to the breast is extremely rare. Here, we describe the case of an 84-year-old woman who had the incidental finding of appendiceal adenocarcinoma following emergency laparoscopic appendectomy. She declined further operative or adjuvant treatment for her disease. She represented 1\u2009year later with metastatic appendiceal adenocarcinoma disease to her left breast. A simple mastectomy for symptomatic treatment was performed. In this report, we describe the first case of appendiceal adenocarcinoma metastases to the breast. Due to its rarity, there is a paucity of evidence related to the management of this condition. The limited evidence is reviewed and discussed.<\/jats:p>","DOI":"10.1136\/bcr-2020-240808","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T11:16:59Z","timestamp":1620991019000},"page":"e240808","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Appendiceal adenocarcinoma with breast metastases"],"prefix":"10.1136","volume":"14","author":[{"given":"Timothy","family":"Davies","sequence":"first","affiliation":[{"name":"General Surgery, University Hospital Crosshouse, Kilmarnock, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarak","family":"Chouari","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Crosshouse, Kilmarnock, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Ray","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Crosshouse, Kilmarnock, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Elgammal","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Crosshouse, Kilmarnock, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"2025082708085782000_14.5.e240808.1","unstructured":"Cancer Research UK . Bowel cancer statistics | Cancer research UK. Bowel cancer statistics, 2017."},{"key":"2025082708085782000_14.5.e240808.2","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7819-7-51","article-title":"Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance","volume":"7","author":"Lohsiriwat","year":"2009","journal-title":"World J Surg Oncol"},{"key":"2025082708085782000_14.5.e240808.3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/his.13324","article-title":"The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei","volume":"71","author":"Carr","year":"2017","journal-title":"Histopathology"},{"key":"2025082708085782000_14.5.e240808.4","doi-asserted-by":"crossref","unstructured":"Siegel RL , Miller KD , Jemal A . Cancer statistics. CA Cancer J Clin 2018;2018.","DOI":"10.1891\/9780826121646.0002"},{"key":"2025082708085782000_14.5.e240808.5","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000018016","article-title":"Breast metastasis from colorectal cancer treated by multimodal therapy: case report and literature review","volume":"98","author":"Hsieh","year":"2019","journal-title":"Medicine"},{"key":"2025082708085782000_14.5.e240808.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.05.025"},{"key":"2025082708085782000_14.5.e240808.7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0035-1564433","article-title":"Management of appendix cancer","volume":"28","author":"Kelly","year":"2015","journal-title":"Clin Colon Rectal Surg"},{"key":"2025082708085782000_14.5.e240808.8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10589"},{"key":"2025082708085782000_14.5.e240808.9","doi-asserted-by":"crossref","unstructured":"McCrea ES , Johnston C , Haney PJ . Metastases to the breast. Am J Roentgenol 1983.","DOI":"10.2214\/ajr.141.4.685"},{"key":"2025082708085782000_14.5.e240808.10","first-page":"158","article-title":"A case of Chloroma, with clinical history and account of post-mortem appearances","volume":"2","year":"1903","journal-title":"Lancet"},{"key":"2025082708085782000_14.5.e240808.11","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.191."},{"key":"2025082708085782000_14.5.e240808.12","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20170197","article-title":"Breast metastases from extramammary malignancies: multimodality imaging aspects","volume":"90","author":"Bitencourt","year":"2017","journal-title":"Br J Radiol"},{"key":"2025082708085782000_14.5.e240808.13","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126780.10029.f0"},{"key":"2025082708085782000_14.5.e240808.14","doi-asserted-by":"crossref","first-page":"264","DOI":"10.14740\/gr1062w","article-title":"And right-sided colorectal cancer: a focused review of literature","volume":"11","author":"Baran","year":"2018","journal-title":"Gastroenterol Res"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:09:05Z","timestamp":1756307345000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,14]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/bcr-2020-240808"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240808","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}