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Although main side effects of antibiotic drugs used for toxoplasmosis are well known, mostly from malaria treatment, there is a lack of information about occurrence in pregnant woman treated for toxoplasmosis. We report a case of a healthy pregnant woman with primary toxoplasmosis infection in the second trimester, who developed a severe adverse reaction in form of hypersensitivity pneumonia after antibiotic treatment with pyrimethamine and sulfadiazine and discuss the literature.<\/jats:p>","DOI":"10.1136\/bcr-2020-240809","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:09:43Z","timestamp":1614596983000},"page":"e240809","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["What obstetricians should be aware of: serious side effects of antibiotic toxoplasmosis treatment in pregnancy"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3524-2371","authenticated-orcid":false,"given":"Sara","family":"Ardabili","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Kohl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclseven","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hodel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2025082803545395000_14.3.e240809.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.10.006"},{"key":"2025082803545395000_14.3.e240809.2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200105000-00025"},{"key":"2025082803545395000_14.3.e240809.3","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu077"},{"key":"2025082803545395000_14.3.e240809.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70224-3"},{"key":"2025082803545395000_14.3.e240809.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08220-8"},{"key":"2025082803545395000_14.3.e240809.6","first-page":"1","article-title":"Toxoplasmosis during pregnancy and infancy. 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