{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:07:56Z","timestamp":1764079676266,"version":"3.44.0"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,17]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Antisynthetase syndrome (anti-SS) is a rare systemic autoimmune disease characterised by autoantibodies against aminoacyl-tRNA synthetases manifesting as one or more components of the classic triad: interstitial lung disease, arthritis and myositis. While it is well-recognised that autoimmune rheumatological disorders in general can contribute to multiple pregnancy complications, very little is known about how anti-SS itself affects pregnancy outcomes. Described here is the case of a 26-year-old pregnant woman with anti-SS whose pregnancy course was complicated by placental dysfunction and subsequent extremely premature delivery at 24 weeks\u2019 gestation. This report presents a review of the literature to date and discusses potential pregnancy complications associated with anti-SS and their subsequent targeted management.<\/jats:p>","DOI":"10.1136\/bcr-2020-240929","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T12:41:42Z","timestamp":1620736902000},"page":"e240929","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Premature live birth in a woman with antisynthetase syndrome following recurrent miscarriages"],"prefix":"10.1136","volume":"14","author":[{"given":"Monique","family":"Kowitz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Queensland Health, Herston, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Chakradeo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashleigh","family":"Hennessey","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Wolski","sequence":"additional","affiliation":[{"name":"Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"2025082710413132000_14.5.e240929.1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/2397198320902667","article-title":"Antisynthetase syndrome: a distinct disease spectrum","volume":"5","author":"Huang","year":"2020","journal-title":"J Scleroderma Relat Disord"},{"key":"2025082710413132000_14.5.e240929.2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/ar3227","article-title":"Managing pregnancy in inflammatory rheumatological diseases","volume":"13","author":"Jain","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"2025082710413132000_14.5.e240929.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem156"},{"key":"2025082710413132000_14.5.e240929.4","unstructured":"Queensland Clinical Guidelines . Venous thromboembolism (VTE) prophylaxis in pregnancy and the puerperium [Internet]. Brisbane, AU: Queensland Health, 2020: 24. https:\/\/www.health.qld.gov.au\/__data\/assets\/pdf_file\/0011\/140024\/g-vte.pdf"},{"key":"2025082710413132000_14.5.e240929.5","unstructured":"Department of Health . Clinical Practice Guidelines: Pregnancy Care [Internet]. Canberra, AU: Australian Government Department of Health, 2020: 339. https:\/\/www.health.gov.au\/sites\/default\/files\/documents\/2021\/02\/pregnancy-care-guidelines-pregnancy-care-guidelines.pdf"},{"key":"2025082710413132000_14.5.e240929.6","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-011-0176-8"},{"key":"2025082710413132000_14.5.e240929.7","unstructured":"Saikumar H , Maselli D , Nambiar A . With child \u2013 a case of antisynthetase syndrome in pregnancy. Poster session presented at: AJRCCM Conference; May 19-24, Washington, 2017."},{"key":"2025082710413132000_14.5.e240929.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91318-1"},{"key":"2025082710413132000_14.5.e240929.9","unstructured":"Giattino SL , Eudy AM , Clowse ME . Pregnancy outcomes in patients with interstitial lung disease related to autoimmune disease and sarcoidosis. Poster session presented at: 2018 ACR\/ARHP Annual Meeting; Oct 19-24, Chicago, 2018."},{"key":"2025082710413132000_14.5.e240929.10","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.autrev.2016.07.014","article-title":"Critical review of the current recommendations for the treatment of systemic inflammatory rheumatic diseases during pregnancy and lactation","volume":"15","author":"Levy","year":"2016","journal-title":"Autoimmun Rev"},{"key":"2025082710413132000_14.5.e240929.11","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12833"},{"key":"2025082710413132000_14.5.e240929.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.056"},{"key":"2025082710413132000_14.5.e240929.13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10024-003-8083-2","article-title":"Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns","volume":"7","author":"Redline","year":"2004","journal-title":"Pediatr Dev 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