{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:22:52Z","timestamp":1779268972605,"version":"3.51.4"},"reference-count":19,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,3,5]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>A 71-year-old woman was referred to the endocrinology clinic to investigate postmenopausal hirsutism with 10 years of evolution. She had history of regular menses and menopause with 50 years old. Physical examination showed a male pattern facies, deepening of the voice, androgenic alopecia and hirsutism with a score of 23 according to the modified Ferriman-Gallwey scale. Testosterone and androstenedione were increased. Transvaginal ultrasound, abdominal and pelvic CT showed uterine fibroids with no pathological findings in the adrenals or ovaries. Since she had postmenopausal vaginal bleeding, uterine fibroids and suspicion of an ovarian source for her hyperandrogenism, total hysterectomy and bilateral oophorectomy were performed. Histopathological diagnosis was a Leydig cell tumour located in left ovary and endometrial carcinoma. Improvement of hirsutism was started to notice 1\u2009month after the surgery and she was referred to the oncology clinic for adjuvant treatment.<\/jats:p>","DOI":"10.1136\/bcr-2020-240937","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T12:20:33Z","timestamp":1615983633000},"page":"e240937","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Ovarian Leydig cell tumor and postmenopausal hirsutism with signs of virilisation"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7895-6542","authenticated-orcid":false,"given":"C\u00e1tia","family":"Ferrinho","sequence":"first","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eug\u00e9nia","family":"Silva","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Sequeira Duarte","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"2025082712333609000_14.3.e240937.1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr042"},{"key":"2025082712333609000_14.3.e240937.2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1210\/jc.2018-00241","article-title":"Evaluation and treatment of hirsutism in premenopausal women: an endocrine Society clinical practice guideline","volume":"103","author":"Martin","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082712333609000_14.3.e240937.3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0468"},{"key":"2025082712333609000_14.3.e240937.4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1683"},{"key":"2025082712333609000_14.3.e240937.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04040.x"},{"key":"2025082712333609000_14.3.e240937.6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0542"},{"key":"2025082712333609000_14.3.e240937.7","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4183\/aeb.2017.356","article-title":"Menopausal Androgen Excess - Associated Cardio-Metabolic Risk: Clues for Ovarian Leydig Cell Tumour (Case Report and Mini-Review of Literature)","volume":"13","author":"Gheorghisan-Galateanu","year":"2017","journal-title":"Acta Endo"},{"key":"2025082712333609000_14.3.e240937.8","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000002461"},{"key":"2025082712333609000_14.3.e240937.9","first-page":"18","article-title":"Hiperandrogenismo POR tumor de Leydig do ov\u00e1rio produtor de testosterona","volume":"10","author":"Nunes","year":"2015","journal-title":"Rev Port Endocrinol Diabetes Metab"},{"key":"2025082712333609000_14.3.e240937.10","first-page":"113","article-title":"Um Caso Raro De Hiperandrogenismo - Tumor Ov\u00e1ricoBilateral de C\u00e9lulas de Leydig","volume":"23","author":"Marcelino","year":"2010","journal-title":"Acta Med Port"},{"key":"2025082712333609000_14.3.e240937.11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/762745","article-title":"Ovarian Leydig cell hyperplasia: an unusual case of virilization in a postmenopausal woman","volume":"2014","author":"Mehta","year":"2014","journal-title":"Case Rep Endocrinol"},{"key":"2025082712333609000_14.3.e240937.12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/09513590.2010.490611","article-title":"Pure Leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis","volume":"27","author":"Yetkin","year":"2011","journal-title":"Gynecol Endocrinol"},{"key":"2025082712333609000_14.3.e240937.13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1210\/jc.2013-3108","article-title":"A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism","volume":"99","author":"Kozan","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082712333609000_14.3.e240937.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01792.x"},{"key":"2025082712333609000_14.3.e240937.15","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3892\/ol.2014.2251","article-title":"Ovarian steroid cell tumor, not otherwise specified: a rare case of postmenopausal vaginal bleeding","volume":"8","author":"Wan","year":"2014","journal-title":"Oncol Lett"},{"key":"2025082712333609000_14.3.e240937.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01588-5"},{"key":"2025082712333609000_14.3.e240937.17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4137\/CCRep.S10555","article-title":"Virilizing leydig-sertoli cell ovarian tumor associated with endometrioid carcinoma of the endometrium in a postmenopausal patient: case report and general considerations","volume":"5","author":"Di Giacinto","year":"2012","journal-title":"Clin Med Insights Case Rep"},{"key":"2025082712333609000_14.3.e240937.18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1210\/jc.2013-2905","article-title":"Measurement of estradiol--challenges ahead","volume":"99","author":"Stanczyk","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082712333609000_14.3.e240937.19","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0064"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:33:42Z","timestamp":1756323222000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,17]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1136\/bcr-2020-240937"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240937","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}