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Imaging revealed a 75 mm left lobular lung mass with chest wall invasion, metastatic bony and soft-tissue deposits and spinal cord compression at T5 level. Lung biopsy, for suspected metastatic lung cancer, surprisingly showed features of plasmablastic myeloma. Protein electrophoresis demonstrated 2 g\/L of IgG lambda paraproteinaemia and an increase in lambda light chains with reduced kappa\/lambda ratio of 0.01. Bone marrow biopsy did not show evidence of infiltration by disease. The patient received radiotherapy to the spine; responded to third-line chemotherapy and received autologous stem cell transplant. This case adds to the rare causes of lung mass and is the first reported case of plasmablastic myeloma diagnosed on lung biopsy.<\/jats:p>","DOI":"10.1136\/bcr-2020-240998","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T12:21:19Z","timestamp":1616156479000},"page":"e240998","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Rare case of plasmablastic myeloma diagnosed on lung biopsy"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9079-8930","authenticated-orcid":false,"given":"Benjamin","family":"Ayeboa-Sallah","sequence":"first","affiliation":[{"name":"Medicine, East Sussex Healthcare NHS Trust, Saint Leonards-on-Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Qutab","sequence":"additional","affiliation":[{"name":"Medicine, East Sussex Healthcare NHS Trust, Saint Leonards-on-Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Grace","sequence":"additional","affiliation":[{"name":"Medicine, East Sussex Healthcare NHS Trust, Saint Leonards-on-Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Sharma","sequence":"additional","affiliation":[{"name":"Medicine, East Sussex Healthcare NHS Trust, Saint Leonards-on-Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"2025082701503144000_14.3.e240998.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442"},{"key":"2025082701503144000_14.3.e240998.2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/jamaoncol.2018.2128","article-title":"Global burden of multiple myeloma: a systematic analysis for the global burden of disease study 2016","volume":"4","author":"Cowan","year":"2018","journal-title":"JAMA Oncol"},{"key":"2025082701503144000_14.3.e240998.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60221-X"},{"key":"2025082701503144000_14.3.e240998.4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404955"},{"key":"2025082701503144000_14.3.e240998.5","first-page":"155","article-title":"Multiple myeloma causing interstitial pulmonary infiltrates and soft-tissue plasmacytoma","volume":"24","author":"Lok","year":"2018","journal-title":"Respir Med Case Rep"},{"key":"2025082701503144000_14.3.e240998.6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.9290"},{"key":"2025082701503144000_14.3.e240998.7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.morpho.2015.02.001","article-title":"Plasma cell morphology in multiple myeloma and related disorders","volume":"99","author":"Ribourtout","year":"2015","journal-title":"Morphologie"},{"key":"2025082701503144000_14.3.e240998.8","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPENJ68FFBRIYB"},{"key":"2025082701503144000_14.3.e240998.9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701943"},{"key":"2025082701503144000_14.3.e240998.10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/hon.2126","article-title":"Clinical analysis of 36 multiple myeloma patients with extramedullary plasmacytoma invasion of the spinal canal","volume":"33","author":"Zhang","year":"2015","journal-title":"Hematol Oncol"},{"key":"2025082701503144000_14.3.e240998.11","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-227514","article-title":"Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy","volume":"12","author":"Rahim","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025082701503144000_14.3.e240998.12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/01676830.2018.1490437","article-title":"Five cases of orbital extramedullary plasmacytoma: diagnosis and management of an aggressive malignancy","volume":"38","author":"Wang","year":"2019","journal-title":"Orbit"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-240998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:50:40Z","timestamp":1756284640000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-240998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,19]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1136\/bcr-2020-240998"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-240998","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}