{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:40:02Z","timestamp":1756370402977,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,4,2]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>The authors report a case of fungal otitis media complicated by extension of the infection into adjacent structures causing apical petrositis and subsequently involvement of the jugular foramen in a 71-year-old diabetic man. First described in 1907, Gradenigo\u2019s syndrome is a serious but rare clinical triad of acute otitis media, unilateral pain in the distribution of cranial nerve V (trigeminal) and ipsilateral cranial nerve VI (abducens) palsy that commonly presents without all three features and is therefore often missed. In this report, our patient was initially misdiagnosed as having a diabetic cranial neuropathy, and later he developed Vernet\u2019s syndrome. Despite aggressive surgical and medical management, he did poorly and died a few weeks later. Clinicians need to be aware of this serious and life-threatening complication of otitis media in high-risk individuals with diabetes or immunocompromised states, to allow early diagnosis and improved clinical outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2020-241006","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T12:00:28Z","timestamp":1619524828000},"page":"e241006","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Gradenigo\u2019s and Vernet\u2019s syndrome in an adult man with Candida mastoiditis"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-8400","authenticated-orcid":false,"given":"Maria A","family":"Parekh","sequence":"first","affiliation":[{"name":"Neurology, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor H","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Neurology, Baylor College of Medicine, Houston, Texas, USA"},{"name":"Neurology, Michael E DeBakey VA Medical Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"2025082801222294000_14.4.e241006.1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF01930369","article-title":"\u00dcber die Paralyse des Nervus abducens bei otitis","volume":"74","author":"Gradenigo","year":"1907","journal-title":"Archiv f. Ohrenheilkunde"},{"key":"2025082801222294000_14.4.e241006.2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1148\/radiographics.17.5.9308106","article-title":"The jugular foramen: a review of anatomy, masses, and imaging characteristics","volume":"17","author":"Caldemeyer","year":"1997","journal-title":"Radiographics"},{"key":"2025082801222294000_14.4.e241006.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00835.x"},{"key":"2025082801222294000_14.4.e241006.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2003.01043.x"},{"key":"2025082801222294000_14.4.e241006.5","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00013-08"},{"key":"2025082801222294000_14.4.e241006.6","doi-asserted-by":"crossref","first-page":"e00111","DOI":"10.1128\/CMR.00111-18","article-title":"Candida parapsilosis: from genes to the bedside","volume":"32","author":"T\u00f3th","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"2025082801222294000_14.4.e241006.7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-241006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:22:29Z","timestamp":1756369349000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-241006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,27]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/bcr-2020-241006"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-241006","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}